THE SECOND MULTICENTER HEMOPHILIA COHORT STUDY (MHCS-II)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。第二项多中心血友病队列研究旨在评估和前瞻性跟踪4500名暴露于丙型肝炎的血友病患者；大约三分之一的人也将感染艾滋病毒。主要目的是量化肝脏失代偿、肝细胞癌和NH淋巴瘤的发生率，并评估这些疾病病因途径上的临床、遗传学、神经学、血清学和免疫学候选标记物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Second Multicenter Hemophilia Cohort Study aims to evaluate and prospectively follow 4500 persons with hemophilia exposed to hepatitis C; about 1/3 will also be HIV-infected. Primary objectives are to quantify rates of liver decompensation, hepatocellular carcinoma and NH lymphoma and to evaluate candidate clinical, genetic, neurologic, serologic and immunologic markers on the causal pathway for these conditions.