WEIGHT LOSS AND ASTHMA

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。流行病学和基础科学研究有非常有力的证据表明，肥胖可能会影响哮喘。这对美国人民的健康有着非常重要的影响。了解减肥引起的生理和炎症变化将对我们理解肥胖和哮喘之间的关系做出重要贡献。 我们提出了一个前瞻性试验的一个队列的哮喘病人接受胃旁路手术治疗病态肥胖。我们将测量减肥引起的生理和炎症变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is very strong evidence from epidemiological and basic science studies to suggest that obesity may affect asthma. This has very important implications for the health of the US population. Understanding the physiological and inflammatory changes induced by weight loss would make an important contribution to our understanding of the relationship between obesity and asthma. We propose a prospective trial of a cohort of asthmatics undergoing gastric-bypass surgery for morbid obesity. We will measure physiological and inflammatory changes induced by weight loss.