THE ROLE OF INFLAMMATORY POLYMORPHISMS IN COLORECTAL NEOPLASIA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。研究人员建议从大约500名计划进行结肠镜检查的患者身上采集血液。血液样本将被分析致炎细胞因子。促炎细胞因子基因的多态与胃癌的风险增加有关。这项先导性、探索性研究的假设是，结肠癌的发生风险也有类似的增加。研究人员建议从大约500名计划进行结肠镜检查的患者身上采集血液。血液样本将分析促炎症细胞因子：COX-2、IL-1b、IL-2、IL-6、IL-8、IL-10、PPARg和TNFa。他们计划检查患者的红肉消费史、体重指数、癌症病史等；结肠镜检查；以及等位基因分析。受试者将被分成四组：无息肉；低度息肉；高度息肉；结直肠癌。初步数据显示了重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The investigators propose to obtain blood from approximately 500 patients scheduled for screening colonoscopy. The blood samples will be analyzed for pro-inflammatory cytokines. Polymorphisms in pro-inflammatory cytokines are associated with increased risk of gastric cancer. The hypothesis of this pilot, exploratory study is that there is a similar increased risk in the development of carcinoma of the colon. The investigators propose to obtain blood from approximately 500 patients scheduled for screening colonoscopy. The blood samples will be analyzed for pro-inflammatory cytokines: COX-2, IL-1b, IL-2, IL-6, IL-8, IL-10, PPARg, and TNFa. They plan to examine patients for history of red meat consumption, BMI, history of cancer, etc; colonoscopy; and allelic analysis. Subjects will be stratified into four populations: no polyps; low-grade polyps; high-grade polyps; colorectal cancer. Preliminary data show significance.