COGNITION AND IMAGING IN TRAUMATIC BRAIN INJURY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是探讨成人（18-65岁）创伤性脑损伤（TBI）幸存者与健康对照者的认知和脑结构差异。该项目将试图证明脑外伤后微结构白质完整性可能受损，这种创伤可能与神经认知功能受损有关。我们建议使用弥散张量成像（DTI）来研究TBI患者的白质异常，这是一种磁共振成像（MRI）方法，以前从未用于探索这一患者群体。这些发现可以增加我们对脑外伤如何影响白质和认知的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to investigate the cognitive and structural brain differences between adult (ages 18-65) survivors of a Traumatic Brain Injury (TBI) and healty controls. This project will seek to demonstrate that microstructural white matter integrity may be compromised after TBI and that this trauma may be associated with impaired neurocognitive functioning. We propose to investigate white matter abnormalities in TBI patients by using Diffusion Tensor Imaging (DTI), a magnetic resonance imaging (MRI) method that has not previously been used to explore this patient population. These findings could increase our understanding of how white matter and cognition are affected by TBI.