Innovative Non-Invasive Imaging of Traumatic Brain Injury
创伤性脑损伤的创新非侵入性成像
基本信息
- 批准号:10527640
- 负责人:
- 金额:$ 40.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAffectAgingAnatomyAnimal ModelAttenuatedAxonBiodistributionBiological MarkersBiomechanicsBlood - brain barrier anatomyBlood CirculationBlood Circulation TimeBlood VesselsBrainBrain EdemaBrain InjuriesCellular MembraneCerebrovascular CirculationCerebrovascular systemCessation of lifeChronicClinicalComputers and Advanced InstrumentationContusionsDetectionDiagnosisDiffuseDiffusion Magnetic Resonance ImagingDoseEmergency SituationFerritinFloridaFunctional disorderHalf-LifeHemoglobinHemorrhageHistologicHospitalizationHumanImageImaging DeviceImaging technologyIndividualInjuryIonizing radiationIronIschemiaLifeLinkLiquid substanceMagnetic Resonance ImagingMagnetismMeasuresMethodsMicroscopicMonitorMorbidity - disease rateNoiseOperative Surgical ProceduresOxygenPathologyPatientsPenetrationPerformancePersonsPhysiologicalPre-Clinical ModelPrincipal InvestigatorPrognosisPropertyQuantitative EvaluationsRecording of previous eventsRecoveryReportingResearchResearch PersonnelResolutionRodent ModelSecondary toSeveritiesSignal TransductionSiteSkull FracturesSurvivorsSwellingT2 weighted imagingTestingTimeTissuesTracerTraumatic Brain InjuryUniversitiesWorkX-Ray Computed Tomographybiomaterial compatibilityblood-brain barrier disruptionclinical imagingcohortcontrolled cortical impactdensitydisabilityimagerimaging capabilitiesimaging detectionimaging modalityimprovedin vivoinnovationinstrumentationiron oxidemagnetic fieldmechanical forcemild traumatic brain injurymolecular imagingmouse modelnanoparticleneurophysiologynon-invasive imagingoptical imagingparticlepre-clinicalquantitative imagingroutine imagingspectroscopic imagingsuperparamagnetismtoolwhite matterwhite matter damage
项目摘要
Project Summary
Traumatic brain injury (TBI) occurs due to the transient application of mechanical force to the brain, which
causes damage to cellular membranes, axons, and brain vasculature. TBI affects millions of people in the US
each year, resulting in hundreds of thousands of hospitalizations, thousands of deaths, and significant disability
in survivors. In addition to acute injury, TBI leads to progressive pathophysiology, including focal bleeding and
transient opening of the blood brain barrier (BBB). Accurate and fast diagnosis of severity of TBI is necessary to
better prescribe treatments and reduce associated death, morbidity, and disability. However, diagnosis of TBI
often relies on patient history, subjective complaints, and neurophysiological status, and classifying severity
remains challenging. Computed tomography and magnetic resonance imaging are fast and accurate for injuries
requiring emergency surgery but are limited to chronic issues such as excessive brain bleeding and swelling.
Magnetic resonance imaging (MRI) can evaluate white matter micropathology of TBI in cohorts but fail to
evaluate TBI in individuals. Therefore, innovative non-invasive imaging technologies are necessary to
improve TBI diagnosis and accelerate research at the clinical and pre-clinical stage.
This proposal will apply an innovative imaging modality called magnetic particle imaging (MPI) to monitor
vascular pathophysiology of TBI. MPI enables non-invasive, unambiguous, and quantitative imaging of the
biodistribution of biocompatible superparamagnetic iron oxide (SPION) tracers. Application of MPI to monitor
TBI consists of systemic administration of SPIONs that accumulate at sites of local BBB disruption, resulting in
a signal that is proportional to SPION MPI performance, rate of accumulation, and accumulation time. The PI
developed a new synthesis method resulting in SPIONs with enhanced MPI performance and preliminary results
demonstrate these SPIONs are superior to commercially available nanoparticles and possess long blood
circulation half-life. The PI hypothesizes that MPI using SPIONs optimized for sensitivity and blood circulation
time will be a powerful non-invasive complementary imaging tool to study TBI in pre-clinical rodent models. This
hypothesis will be tested through two specific aims. Studies in Aim 1 will determine SPION accumulation in a
controlled cortical impact (CCI) injury mouse model of TBI as a function of dose and time of administration and
will establish histological factors linked to MPI measures of SPION accumulation. Studies in Aim 2 will compare
MPI measures of SPION accumulation in the CCI injury mouse model against MRI measures of SPION
accumulation and other changes associated with TBI. Together, the proposed studies will test the potential of
MPI for non-invasive, sensitive, and quantitative evaluation of TBI in pre-clinical models by comparison to ground
truth and established non-invasive imaging modalities. The proposed work is supported by a diverse team of
investigators with complementary expertise and access to state-of-the-art MPI and MRI instrumentation.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Carlos M Rinaldi-Ramos其他文献
Carlos M Rinaldi-Ramos的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Carlos M Rinaldi-Ramos', 18)}}的其他基金
NIH Administrative Supplement to Promote Diversity in Health Related Research
NIH 促进健康相关研究多样性的行政补充
- 批准号:
10876754 - 财政年份:2023
- 资助金额:
$ 40.07万 - 项目类别:
Nanoparticles to Track T Cell Immunotherapy Using Magnetic Particle Imaging
使用磁粒子成像追踪 T 细胞免疫治疗的纳米粒子
- 批准号:
10365339 - 财政年份:2022
- 资助金额:
$ 40.07万 - 项目类别:
Nanoparticles for In Vivo Labeling of T Cells During Cancer Immunotherapy
用于癌症免疫治疗期间 T 细胞体内标记的纳米颗粒
- 批准号:
10450938 - 财政年份:2022
- 资助金额:
$ 40.07万 - 项目类别:
Nanoparticles for In Vivo Labeling of T Cells During Cancer Immunotherapy
用于癌症免疫治疗期间 T 细胞体内标记的纳米颗粒
- 批准号:
10634620 - 财政年份:2022
- 资助金额:
$ 40.07万 - 项目类别:
Nanoparticles to Track T Cell Immunotherapy Using Magnetic Particle Imaging
使用磁粒子成像追踪 T 细胞免疫治疗的纳米粒子
- 批准号:
10621153 - 财政年份:2022
- 资助金额:
$ 40.07万 - 项目类别:
Magnetically Templated Regeneration Scaffolds for Nerve Injury Repair
用于神经损伤修复的磁模板再生支架
- 批准号:
8954155 - 财政年份:2015
- 资助金额:
$ 40.07万 - 项目类别:
Modeling of the Magnetic Particle Imaging Signal Due to Magnetic Nanoparticles
磁性纳米粒子产生的磁性粒子成像信号的建模
- 批准号:
9024525 - 财政年份:2015
- 资助金额:
$ 40.07万 - 项目类别:
Magnetically Templated Regeneration Scaffolds for Nerve Injury Repair
用于神经损伤修复的磁模板再生支架
- 批准号:
9086452 - 财政年份:2015
- 资助金额:
$ 40.07万 - 项目类别:
相似海外基金
Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
- 批准号:
495182 - 财政年份:2023
- 资助金额:
$ 40.07万 - 项目类别:
Parkinson's disease and aging affect neural activation during continuous gait alterations to the split-belt treadmill: An [18F] FDG PET Study.
帕金森病和衰老会影响分体带跑步机连续步态改变期间的神经激活:[18F] FDG PET 研究。
- 批准号:
400097 - 财政年份:2019
- 资助金额:
$ 40.07万 - 项目类别:
The elucidation of the mechanism by which intestinal epithelial cells affect impaired glucose tolerance during aging
阐明衰老过程中肠上皮细胞影响糖耐量受损的机制
- 批准号:
19K09017 - 财政年份:2019
- 资助金额:
$ 40.07万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Does aging of osteocytes adversely affect bone metabolism?
骨细胞老化会对骨代谢产生不利影响吗?
- 批准号:
18K09531 - 财政年份:2018
- 资助金额:
$ 40.07万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Links between affect, executive function, and prefrontal structure in aging: A longitudinal analysis
衰老过程中情感、执行功能和前额叶结构之间的联系:纵向分析
- 批准号:
9766994 - 财政年份:2018
- 资助金额:
$ 40.07万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9320090 - 财政年份:2017
- 资助金额:
$ 40.07万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
10166936 - 财政年份:2017
- 资助金额:
$ 40.07万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9761593 - 财政年份:2017
- 资助金额:
$ 40.07万 - 项目类别:
Experimental Model of Depression in Aging: Insomnia, Inflammation, and Affect Mechanisms
衰老过程中抑郁症的实验模型:失眠、炎症和影响机制
- 批准号:
9925164 - 财政年份:2016
- 资助金额:
$ 40.07万 - 项目类别:
Experimental Model of Depression in Aging: Insomnia, Inflammation, and Affect Mechanisms
衰老过程中抑郁症的实验模型:失眠、炎症和影响机制
- 批准号:
9345997 - 财政年份:2016
- 资助金额:
$ 40.07万 - 项目类别: