INTERACTIONS BETWEEN PROGESTERONE AND COCAINE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本研究的目的是探讨吸烟可卡因和外源性孕酮之间的特定相互作用。一种假设是，在女性卵泡期给予外源性孕酮会减少对可卡因的主观反应以及可卡因自我给药。当血浆雌二醇和孕酮浓度正常较低时，将在月经期间给予孕酮或安慰剂治疗。月经周期的早期卵泡期为研究外源性孕酮的作用提供了机会，同时最大限度地减少了内源性雌二醇和孕酮的潜在混杂影响。对男性的假设是，黄体酮会减弱对可卡因的渴望和使用。该研究的一个具体目的是在实验室模型中描述孕酮对吸烟可卡因的生理、主观和强化作用的剂量相关效应。健康的可卡因依赖女性受试者将在月经早期（连续两个月经周期期间）入住GCRC，并开始口服黄体酮，每日两次。男性受试者将在连续两个月的同一时间入住GCRC，并按照女性接受给药。所有受试者都将经历适应期，在适应期内，他们将被引入方案和一剂可卡因。在连续2天（3 & 4）的实验期间，他们将获得一份吸食可卡因的样品剂量，并可以选择通过计算机数学测试获得5个代币。然后，他们可以用这些代币（最多5个）换取金钱（5.00）或一剂吸食可卡因。将监测生理参数，GCRC护理人员将在实验期间建立IV并抽血。一名医生将出席。本研究将允许研究孕酮的剂量效应。所用可卡因剂量与先前关于GCRC的研究相同。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to explore specific interactions between smoked cocaine and exogenously administered progesterone. One hypothesis is that exogenous progesterone, adminstered during the follicular phase in women will reduce subjective responses to cocaine as well as cocaine self-administration. Progesterone or placebo treatment will be given during their menses when plasma estradiol and progesterone concentrations are normally low. This early follicular phase of the menstrual cycle provides an opportunity to investigate the effects of exogenously administered progesterone while minimizing the potential confounding influence of endogenous estradiol and progesterone. The hypothesis for men is that progesterone will attenuate the desire for and use of cocaine. A specific aim of the study will be to characterize the dose-related effects of progesterone on the physiological, subjective and reinforcing effects of smoked cocaine in a laboratory model. Healthy cocaine dependent female subjects will be admitted to the GCRC early in their menses (during two consecutive menstrual cycles) and begin oral progesterone, given BID. Male subjects will be admitted to the GCRC at the same time two consecutive months and receive dosing as per the females. All subjects will undergo an adaption phase where they will be introduced to the protocol and a dose of cocaine. During the experimental sessions on 2 consecutive days (3 & 4) they will be given a sample dose of smoked cocaine and have the option to earn 5 tokens from doing a computer math test. They may then exchange these tokens (up to 5) for money (5.00) or a dose of smoked cocaine. Physiologic parameters will be monitored and GCRC nursing personnel will establish IV's and draw blood during the experiment. A physician will be in attendance. This study will allow dose-effects of progesterone to be studied. The doses of cocaine used are the same as in previous studies on the GCRC.