EARLY TREATMENT OF ALS W NUTRITION & NON-INVASIVE POSITIVE PRESSURE VENTILATION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的主要目的是探讨常规与早期积极的营养和呼吸干预对生存、功能结局和生活质量的影响。次要目标包括开发和验证提高NIPPV（无创正压通气）耐受性的策略；肌萎缩侧索硬化症患者早期呼吸功能障碍的评估及能量平衡的测定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this study is to investigate the effect of conventional versus early aggressive nutritional and respiratory intervention on survival, functional outcome and quality of life. Secondary objectives include the development and validation of strategies to improve tolerability of NIPPV (non-invasive positive pressure ventilation); evaluation of measurements of early respiratory dysfunction and determination of energy balance in ALS.