MOTION PROCESSING IN SCHIZOPHRENIA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。平滑追踪眼动异常（spm）在约40%的精神分裂症患者及其一定比例的未患病的一级生物学亲属中被观察到。后者表明SPEM缺陷标志着精神分裂症的倾向性。当前应用的目标是确定精神分裂症中SPEM表型的特定神经认知机制。特定的生理缺陷可能更接近于基因的影响，因此更准确地识别具有精神分裂症易感性的个体的同质亚群。这项工作对在精神分裂症的分子遗传和病理生理研究中使用精制表型具有重要意义。我们将测试精神分裂症患者、他们有精神分裂症倾向的一级亲属（即精神分裂症谱系人格（SSP）症状，SSP）和没有精神疾病家族史的社区受试者。这项研究将分两个阶段进行。在初始阶段，我们将从每个诊断类别中测试5-10个受试者组，以确保新设计的任务和设备正常工作。一旦试点测试完成，我们将招募30名精神分裂症患者，30名患有SSP的一级亲属，60名没有精神分裂症家族史的健康社区受试者（其中30名在没有精神疾病家族史的情况下表现出SSP症状）。这些受试者将接受一系列认知、运动感知和眼动任务。其中一些测试将在图拉诺博士在约翰霍普金斯大学的实验室进行。所有测试均采用标准的非侵入性方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Smooth pursuit eye movement abnormality (SPEM) is observed in about 40% of schizophrenic patients and a proportion of their non-ill, first-degree biological relatives. The latter suggests that the SPEM deficit marks schizophrenia liability. The goal of the current application is to identify the specific neurocognitive mechanisms underlying the SPEM phenotype in schizophrenia. A specific physiological deficit is likely to be more proximal to the effects of genes, and therefore more accurate in identifying a homogenous subgroup of individuals with schizophrenia liability. This work has significance for use of the refined phenotype in molecular genetic and pathophysiologic studies of schizophrenia. We will test patients with schizophrenia, their 1st degree relatives who show other evidence of schizophrenia liability (i.e., schizophrenia spectrum personality (SSP) symptoms, SSP), and community subjects with no family history of psychotic illness. The study will be carried in out in two phases. In the initial phase we will test groups of 5-10 subjects from each diagnostic category in order to insure that newly designed tasks and equipment are working properly. Once the pilot testing is completed, we will recruit 30 subjects with schizophrenia, 30 1st degree relatives with SSP, 60 healthy, community subjects with no family history of schizophrenia (30 of whom exhibit SSP symptoms in the absence of a family history of psychotic illness). A battery of cognitive, motion perception and eye movement tasks will be administered in these subjects. Some of the testing will be carried out in Dr. Turano's laboratory at Johns Hopkins. Standard non-invasive methods are used for all testing.