TOBACCO USE IN TEENS AND YOUNG ADULTS WITH AND WITHOUT ATTENTION DEFICIT HYPE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。越来越多的证据表明，患有多动症的儿童和青少年吸烟的可能性几乎是没有多动症儿童的两倍。尽管在ADHD人群中吸烟和戒烟的关联更大，但对于为什么有些患有ADHD的年轻人成为固定吸烟者而另一些人却没有，我们知之甚少。有可能一些患有多动症的人在遗传和/或心理社会方面受到保护，不会发展到吸烟的地步，而另一些人则受到生物/遗传或心理社会的影响，从而增加了他们的风险。为了填补我们知识上的空白，我们对在初级医疗诊所接受ADHD治疗的青少年进行了一项横断面研究。我们正在研究吸烟的风险和保护因素。迄今为止，共有36名ADHD受试者和64名非ADHD受试者参与了本项目。正在进行基因分型分析，所有行为数据已录入数据库并进行验证。在完成受试者登记和所有DNA基因分型后，我们将进行统计分析以回答感兴趣的主要研究问题。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is a growing body of evidence to suggest that children and adolescents with ADHD are nearly 2x more likely to smoke than children without ADHD. Despite the higher association of smoking and greater difficulty quitting in the ADHD population, little is know about why some youth with ADHD become established smokers while others do not. It is possible that some persons with ADHD are genetically and/or psychosocially protected from progressing to established smoking, whereas others are exposed to biologic/genetic or psychosocial influences that increase their risk. To fill this gap in our knowledge, we are conducting a cross-sectional study with adolescents attending a primary medical care clinic for their treatment of ADHD. We are examining risk and protective factors for smoking. To date, a total of 36 subjects with ADHD and 64 subjects without ADHD have participated in this project. Genotyping analysis is being conducted, and all behavioral data have been entered into a database and verified. Upon the completion of subject enrollment and all DNA genotyping we will conduct statistical analyses to answer the primary research questions of interest.