FUNCTIONAL MRI STUDIES OF THE PATHOPHYSIOLOGY OF DYSLEXIA IN ADULTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。迫切需要对阅读障碍的病理学有一个更好的理解。这些实验的结果将提供有关发育性阅读障碍的视觉、听觉和语音异常的神经底物的新信息，并可能导致开发更准确的阅读障碍诊断工具。此外，我们将把深度失聪的人纳入我们的研究中，以使我们能够了解听觉处理对大脑中阅读和视觉处理的神经组织的影响，以及它对阅读能力的表现。将在这些小组中研究指导、交流和干预的作用，以研究通过获取干预前后的fMRI数据确定的教学方法的生理和行为后果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is an urgent need for an improved understanding of the pathology of dyslexia. The results of these experiments will provide new information concerning the neural substrates responsible for visual, auditory, and phonological abnormalities characteristic of developmental dyslexia and may lead to the development of more accurate diagnostic tools for dyslexia. In addition, we will include profoundly deaf individuals in our studies in order to allow us to understand the impact of auditory processing on the neural organization for reading and visual processing in the brain and its manifestation on reading ability. The role of instruction, communication and intervention will be studied in these groups in order to study the physiological as well as behavioral consequences of instructional approaches ascertained by acquiring fMRI data prior to and after intervention.