CORE 3: INFRASTRUCTURE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。生物医学工程系，HiT中心成员。HiT中心是专门为支持和促进大型、跨学科和技术开发项目而设计的，例如为这个TCNP提出的项目。HiT中心由多个教师研究小组组成，拥有先进的核心设施；因此，支持拟议项目的相当大的基础设施已经存在。我们建议在这个基础设施中增加一个计算生物学核心，以满足TCNP研究人员的特定计算需求。在计算生物学支持核心，Bader博士和他在生物医学工程的同事Andre Levchenko博士将为该TCNP的所有成员提供计算支持服务。这两位都是蛋白质相互作用网络和途径计算生物学方面的专家。Levchenko博士在动态网络和模拟代谢和信号通路的定量变化方面具有特殊的专长

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Department of Biomedical Engineering and member of the HiT Center. The HiT Center was expressly designed to support and facilitate large, interdisciplinary and technology development projects such as that proposed for this TCNP. The HiT Center consists of several faculty research groups side by side with highly advanced core facilities; thus considerable infrastructure to support the proposed project already exists. We propose to add to this infrastructure a computational biology core designed to meet the specific computational needs of the investigators in the TCNP. In the computational biology support core, Dr. Bader, together with his colleague in Biomedical Engineering, Dr. Andre Levchenko, will provide computational support services for all members of this TCNP. Both of these individuals are experts in the computational biology of protein interaction networks and pathways. Dr. Levchenko has special expertise in dynamic networks and modeling quantitative changes in metabolic and signaling pathways