PROSPECTIVE EVALUATION OF PATIENTS W/ IDIOPATHIC PULMONARY FIBROSIS-IPF REGISTRY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本方案建立了特发性肺纤维化登记研究，以便为I期治疗方案收集足够的IPF患者。该登记研究将纳入自然史研究的人口统计学和临床数据;第二，生理学、高分辨率CT扫描和支气管肺泡灌洗的研究数据，以收集细胞和介质用于病理生理学的前瞻性研究;第三，将监测对标准治疗的反应，以确定细胞和分子与临床结局和生存预测因子的关系。核心实验室用于DNA分离、RNA分离、PCR、寡核苷酸合成和Recornbinant DNA技术。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol establishes a registry for idiopathic pulmonary fibrosis in order to assemble sufficient patients with IPF for phase I therapeutic protocols. The registry will incorporate demographic and clinical data for natural history studies; second, research data on physiology, high resolution CT scans, and bronchoalveolar lavage for cells and mediators to be collected for prospective studies on pathophysiology, and third, response to standard therapies will be mcnitored to determine cellular and molecular relationships to clinical outcome and predictors of survival. The Core Laboratory was utilized for DNA isolation, RNA isolation, PCR, oligonucleotide synthesis, and Recornbinant DNA techniques.