PROSPECTIVE EVALUATION OF PATIENTS W/ IDIOPATHIC PULMONARY FIBROSIS-IPF REGISTRY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该方案建立了特发性肺纤维化的登记，以便为I期治疗方案聚集足够的IPF患者。该登记将纳入自然历史研究的人口学和临床数据；第二，生理学、高分辨率CT扫描和支气管肺泡灌洗的研究数据，为病理生理学的前瞻性研究收集细胞和介体；第三，将监测对标准治疗的反应，以确定细胞和分子与临床结果和生存预测因素的关系。核心实验室用于DNA提取、RNA提取、聚合酶链式反应、寡核苷酸合成和重组DNA技术。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol establishes a registry for idiopathic pulmonary fibrosis in order to assemble sufficient patients with IPF for phase I therapeutic protocols. The registry will incorporate demographic and clinical data for natural history studies; second, research data on physiology, high resolution CT scans, and bronchoalveolar lavage for cells and mediators to be collected for prospective studies on pathophysiology, and third, response to standard therapies will be mcnitored to determine cellular and molecular relationships to clinical outcome and predictors of survival. The Core Laboratory was utilized for DNA isolation, RNA isolation, PCR, oligonucleotide synthesis, and Recornbinant DNA techniques.