PROSPECTIVE EVALUATION OF PATIENTS W/ IDIOPATHIC PULMONARY FIBROSIS-IPF REGISTRY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol establishes a registry for idiopathic pulmonary fibrosis in order to assemble sufficient patients with IPF for phase I therapeutic protocols. The registry will incorporate demographic and clinical data for natural history studies; second, research data on physiology, high resolution CT scans, and bronchoalveolar lavage for cells and mediators to be collected for prospective studies on pathophysiology, and third, response to standard therapies will be mcnitored to determine cellular and molecular relationships to clinical outcome and predictors of survival. The Core Laboratory was utilized for DNA isolation, RNA isolation, PCR, oligonucleotide synthesis, and Recornbinant DNA techniques.