CHRONIC KIDNEY DISEASE IN CHILDREN STUDY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。国家糖尿病、消化和肾脏疾病研究所（NIDDK）肾脏、泌尿和血液疾病科（DKUHD）与国家神经疾病和中风研究所（NINDS）、国家儿童健康和人类发展研究所（NICHD）和国家心脏研究所合作，肺和血液研究所（NHLBI）资助了一项合作协议，包括两个临床协调中心和一个数据协调中心，以开展慢性肾脏疾病（CKD）儿童的前瞻性流行病学研究。本研究的主要目的是确定肾功能下降的危险因素，并确定肾功能的进行性下降如何影响a)神经认知功能和行为；B)心血管疾病的危险因素；c)生长衰竭及其相关的发病率。共有540名患有慢性肾脏疾病的儿童（估计GFR为30-75 ml/min/1.73 m2）将被纳入这项为期4年的前瞻性观察性研究，并接受一系列测试来研究以下假设

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Division of Kidney, Urologic, and Hematologic Diseases (DKUHD) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in collaboration with the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Child Health and Human Development (NICHD) and the National Heart, Lung and Blood Institute (NHLBI) funded a cooperative agreement including two Clinical Coordinating Centers and a Data Coordinating Center to conduct a prospective epidemiological study of children with chronic kidney disease (CKD). The primary goals of this study are to determine the risk factors for decline in kidney function and to define how a progressive decline in kidney function impacts a) neurocognitive function and behavior; b) the risk factors for cardiovascular disease; and c) growth failure and its associated morbidity. A total of 540 children with chronic kidney disease (estimated GFR 30-75 ml/min/1.73 m2) will be enrolled in this prospective observational study over 4 years and undergo a series of tests to study the hypotheses given below