OXIDATIVE STRESS CKD

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。假设:1。慢性肾脏疾病患者氧化应激、炎症和内皮功能障碍增加具有生物学相关性。2. 氧化应激、炎症和内皮功能障碍的增加有助于慢性肾病患者的心血管事件。3. 随着时间的推移，肾功能的进行性丧失会增加慢性肾病患者的氧化应激、炎症和内皮功能障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESES: 1. Increased oxidative stress, inflammation and endothelial dysfunction are biologically linked in patients with chronic kidney disease. 2. Increased oxidative stress, inflammation, and endothelial dysfunction contribute to cardiovascular events in patients with chronic kidney disease. 3. Progressive loss of kidney function over time increases oxidative stress, inflammation, and endothelial dysfunction in patients with chronic kidney disease.