COBRE: UVM: CORE D: TRANSLATIONAL NEUROSCIENCE TRAINING

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这个核心是其支持的第四个年头，目标是提供一个智力环境，鼓励在翻译神经科学的职业发展。此前，CORE曾为两名医学生(Coates和Kelley)提供津贴，以支持他们与Mawe博士和Wellman博士一起进行全日制长凳研究。Coates先生发表了一篇论文，并在国家会议上作了介绍。这一成功促使Coates先生进入密歇根州立大学S博士/博士项目。凯利先生已经毕业，目前是北卡罗来纳大学的一名居民。在这一年里，CORE为两名医科学生(乔利诺和奎克)提供了额外的研究金支持。这些学生与Mawe博士和Cipolla博士一起进行了研究。奎克女士的工作已经发表了一篇论文，乔利诺女士将继续担任她的研究员。今年，潘传菊正在埃肯斯坦博士的实验室进行研究，预计她将与人合著两本出版物。此外，今年Meagan Costedio博士将在Gary Mawe博士的实验室进行研究。她的研究包括一个项目，旨在确定憩室病患者结肠中的5-羟色胺浓度和信号是否发生变化，以及它们与憩室炎患者的结肠相比如何。已经组织了一门课程，说明翻译神经科学研究的进展。本课程提供了对单一神经疾病研究的深入分析。承保的疾病每年都在变化。过去的疾病包括帕金森氏症、多发性硬化症和精神分裂症。今年的课程重点是肌萎缩侧索硬化症。该课程包括每周12次的课程，范围从临床研究到基础分子方法。来自神经学、神经外科、心理学、医学系和解剖学与神经生物学系的教师在这门团队授课的课程中进行合作。此外，今年还有两位外部演讲者贡献了演讲。一个神经科学本科生暑期奖学金项目已经建立。本科生进行为期10周的研究，阅读初级文献，并参加科布雷教职员工的讲座。大约40名学生(大多数来自不同于密歇根州立大学的机构)申请，大约8名被选中。有几个人继续攻读博士研究生课程。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This Core is in its 4th year of support, with the goal to provide an intellectual environment encouraging career development in translational neuroscience. Previously, the core had provided the stipend to support a research fellowship for two medical students (Coates and Kelley) who conducted full-time bench research with Drs. Mawe and Wellman. Mr. Coates¿ published one paper and presented at national meetings. This success motivated Mr. Coates to enter UVM¿s MD/PhD program. Mr. Kelley has graduated and is currently a resident at the University of North Carolina. During the year the core provided additional fellowship support for two medical students (Ciolino and Quick). These students have conducted research with Drs. Mawe and Cipolla. Ms. Quick's work has resulted in one published paper and Ms. Ciolino is continuing her fellowship. This year, Ms. Chuan-Ju Pan is conducting research in Dr. Eckenstein's laboratory, and it is expected that she will co-author two publications. Additionally, this year Dr. Meagan Costedio is conducting research in Dr. Gary Mawe's lab. Her research consists of a project to determine if serotonin concentrations and signaling are altered in the colons of people with diverticulosis, and how they compare with colons of people with diverticulitis. A course illustrating the progress of translational neuroscience research has been organized. The course provides an in-depth analysis of research into a single neurological disease. The disease to be covered changes every year. Past disease entities covered include Parkinson's Disease, Multiple Sclerosis and Schizophrenia. This year's course will focus on Amyotrophic Lateral Sclerosis. The course consists of 12 weekly sessions ranging from clinical research to basic molecular approaches. Faculty from the Departments of Neurology, Neurosurgery, Psychology, Medicine and Anatomy & Neurobiology collaborate in this team-taught course. In addition, two outside speakers contributed lectures this year. An Undergraduate Neuroscience Summer fellowship program has been established. Undergraduates perform 10 weeks of research, read primary literature and attend lectures given by COBRE faculty. Approximately 40 students (most from institutions different from UVM) apply, and approximately 8 are selected. Several have gone on to Ph.D. graduate programs.