ASSESSING POTENTIAL OF MEDICINAL PLANTS IN THE TREATMENT OF TYPE II DIABETES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。药用植物已经被美洲原住民使用了几代人，今天继续用于治疗II型糖尿病。II型糖尿病已日益成为许多美洲原住民社区（以及一般美国人口）的问题。已经确定了几种本地植物可能有助于治疗这种疾病。酚类物质和其他天然存在的次生植物产物已被证明可以刺激胰岛素分泌，调节糖原代谢，并降低胰岛素不敏感性。本研究的目的是确定小鼠口服这些药用植物提取物的效果。具体而言，致死性黄色小鼠将用作本实验的模型受试者。致命的黄色小鼠患有成年肥胖症，并患有II型糖尿病。将在对照组和施用植物提取物剂量的小鼠之间比较葡萄糖和胰岛素的水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Medicinal plants have been used by Native Americans for generations and continue to be used today for the treatment of Type II diabetes. Type II diabetes has increasingly become a problem in many Native American communities (as well as for the American population in general). Several native plants have been identified that may be helpful in treating this condition. Phenolics and other naturally occurring secondary plant products have been shown to stimulate insulin secretion, regulate glycogen metabolism, and reduce insulin insensitivity. The objective of this study will be to determine the effect of extracts of these medicinal plants taken orally by mice. Specifically the lethal yellow mouse will be used as a model subject for this experiment. The lethal yellow mouse suffers from adult onset obesity and is subject to Type II diabetes. Levels of both glucose and insulin will be compared between controls and mice administered doses of plant extracts.