INBRE: UNIVERSITY OF DELAWARE: ADMINISTRATIVE CORE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。特拉华州INBRE年度进展报告（APR） 2006拨款号2P20RR016472-2006行政核心报告核心目标：行政核心在全州范围内领导和协调合作机构之间的项目活动。David S. Weir博士，INBRE PI和Karl V. Steiner博士，INBRE行政总监，也是特拉华州生物技术研究所（DBI）的董事和副董事，领导特拉华州INBRE行政核心。行政核心在第二年的成就包括：1)从BRIN的基础设施建设重点转变为INBRE的研究重点，并在特拉华大学（UD），特拉华州立大学，Christiana Care Health Systems的Helen F. Graham癌症中心和Nemours儿童医院完成了第二年的指导生物医学研究项目。继续在参与机构之间发展健康、建设性的平等伙伴关系。2)作为在特拉华州发展医学研究能力的倡议的一部分，参与了转化性癌症研究中心的组建，涉及DBI和UD生物科学系，Nemours儿童医院，以及该州最大的医疗保健提供者Christiana Care的Helen F. Graham癌症中心。特拉华INBRE的教师正在领导一个由科学家和医生组成的转化研究工作组，该工作组现在每隔六个月召开一次会议，讨论癌症转化研究的最新进展。该小组现在包括特拉华州的研究人员以及来自费城基梅尔癌症中心（杰斐逊医学院）和福克斯蔡斯癌症中心的地区研究人员。谈判正在进行中，包括心血管领域的转化研究。特拉华州的托马斯·杰斐逊大学医学院也在进行类似的谈判，为医科学生和医生开发基于虚拟现实的教育和培训项目。3)征求第二轮INBRE研究提案，更有针对性地关注癌症的基础和转化研究。研究委员会及外聘谘询委员会已批准十三个新项目，将于2006年6月展开。4)制定了实质性的评估流程，包括美国科学促进会（AAAS）每两年进行一次实地考察，特拉华大学教育研究与发展中心（University of Delaware Education Research and Development Center）进行的内部评估流程，以及定期向特拉华INBRE外部咨询委员会（Delaware INBRE External Advisory Board）通报情况。正在开发一个在线用户界面和评价数据库。评价过程的初步产出导致从不良方案中重新分配资金。5)持续开发仪器核心的能力并评估其有效性。例如，由INBRE/COBRE联合资助的生物信息学基础设施支持了特拉华大学在小rna方面的开创性工作。微阵列已经不再被强调，并且已经被纳入包含微阵列、测序和蛋白质生产的多用途核心。6)提高了研究在特拉华大学护理学院的作用，学生参与了教师的研究项目，并推出了一门新课程NURS362，护理研究概念。7)继续在特拉华大学开设了一门新的双重上市课程，化学和生物化学/化学工程467。这门名为《生物化学与生物技术实验室》的课程旨在培养本科生具备参与生物学、生物化学、化学和化学工程研究所需的实验室技能。8)通过本科生暑期实习项目，让23名本科生参与生物医学相关的研究项目。重点继续涉及多元化的学生群体。2005年的小组包括60%的女性和30%的代表性不足的学生，涉及特拉华INBRE所有合作机构的30多名教职员工。9)为INBRE参与者提供指导和领导，以成功实现项目目标。确保所有六个INBRE核心的项目目标得到满足。协调和监督财务和项目管理。10)促使美国国立卫生研究院对特拉华州的资助从2000年的1490万美元增加到2005年的2650万美元。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Delaware INBRE Annual Progress Report (APR) 2006 Grant No. 2P20RR016472-2006 Administrative Core Report Core Objective: The Administrative Core provides statewide leadership and coordination of the program activities among the partner institutions. Dr. David S. Weir, INBRE PI and Dr. Karl V. Steiner, INBRE Administrative Director, who are also Director and Associate Director of the Delaware Biotechnology Institute (DBI), lead the Delaware INBRE Administrative Core. Accomplishments of the Administrative Core in Year 2 include: 1) Transitioned from the infrastructure-building focus of BRIN to a research focus in INBRE, and completed a second year of mentored biomedical research projects at the University of Delaware (UD), Delaware State University, the Helen F. Graham Cancer Center of Christiana Care Health Systems and Nemours Hospital for Children. Continued to develop a healthy, constructive partnership of equals among the participating institutions. 2) Participated in the formation of a Center for Translational Cancer Research as part of an initiative to develop a medical research capability in Delaware, involving DBI and the Department of Biological Sciences at UD, Nemours Hospital for Children, and the Helen F. Graham Cancer Center at Christiana Care, the State¿s largest health care provider. Delaware INBRE faculty are leading a translational research working group of scientists and physicians which now meets at six-month intervals for research updates on translational research in cancer. The group now includes Delaware researchers as well as regional researchers, from Philadelphia¿s Kimmel Cancer Center (Jefferson Medical College) and Fox Chase Cancer Center. Negotiations are underway to include translational research in the cardiovascular area. Parallel negotiations are underway with Thomas Jefferson University, Delaware¿s medical school, to develop virtual-reality based education and training programs for medical students and physicians. 3) Solicited a second round of INBRE research proposals, with a more targeted focus on basic and translational research in cancer. The Research Committee and the External Advisory Board have approved thirteen new projects that begin in June 2006. 4) Developed a substantial evaluation process involving a bi-annual site visit by AAAS, an internal evaluation process conducted by the University of Delaware Education Research and Development Center, and regular briefings to the Delaware INBRE External Advisory Board. Development of an online user interface and evaluation database is underway. Initial output of the evaluation process has resulted in reallocation of funding from a non-performing program. 5) Continued to develop the capability and evaluate effectiveness of instrumentation cores. For example, bioinformatics infrastructure funded jointly by INBRE/COBRE has supported groundbreaking work in small RNAs at the University of Delaware. Microarray has been de-emphasized, and has been incorporated into a multipurpose core containing microarray, sequencing and protein production. 6) Influenced an increase in the role of research in the UD School of Nursing, with students involved in faculty research projects, and the launch of a new course, NURS362, Research Concepts in Nursing. 7) Continued the pilot phase of a new double-listed course at the University of Delaware, Chemistry and Biochemistry/Chemical Engineering 467. The course, entitled Biochemistry and Biotechnology Laboratory is aimed at preparing undergraduates with laboratory skills necessary to participate in research in biology, biochemistry, chemistry, and chemical engineering. 8) Involved a cohort of 23 undergraduates in biomedically-relevant research projects through the summer undergraduate internship program. Emphasis continues to involve a diverse student group. The 2005 group included 60% women and 30% underrepresented students, and involved more than 30 faculty members at all Delaware INBRE partner institutions. 9) Provided guidance and leadership to the INBRE participants toward successful implementation of program goals. Assured that program objectives of all six INBRE Cores are met. Coordinated and oversaw financial and program management. 10) Contributed to the increase in NIH funding to the State of Delaware - from $14.9 Million in 2000 to $26.5 Million in 2005.