UKY DENTAL COBRE: ORAL INFECTIONS: IMPACT ON GESTATIONAL DIABETES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。妊娠糖尿病（GDM）发生在大约5%的孕妇，在怀孕期间发病，分娩后消退。重要的是，近50%的GDM女性最终会在产后3-5年内发展为2型糖尿病。此外，急性和慢性新生儿发病率和死亡率已被描述在新生儿分娩的妇女与GDM。有大量证据表明，牙周病的严重程度是增加2型糖尿病患者，但没有数据可用于GDM对牙周健康的影响。此外，大量数据支持早期观察结果，即与牙周病相关的感染和炎症可能对妊娠期和胎儿生长产生负面影响，导致早产，低出生体重儿的出生。我们的一般假设是，GDM女性比非GDM女性发生更严重牙周病的风险更高，GDM和牙周病的组合将与对孕产妇和胎儿健康的负面影响增加有关。将通过收集（a）牙周状态的临床口腔健康数据以及母体和胎儿结局数据（具体目标1）、（B）微生物牙菌斑样本（具体目标2）和（c）GDM女性和非GDM对照女性的血清样本（具体目标3）来检验该假设。这些前瞻性的临床数据将与基础科学实验室的微生物菌群和宿主反应的评价，以提供深入了解致病机制，有助于负面的母亲和胎儿的结果与炎症性牙周病和GDM。迄今为止，已有25名受试者入组研究。已收集了所有受试者的适当数据。明年将继续招生。将在研究中期和结束时对收集的数据进行统计分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gestational Diabetes Mellitus (GDM) occurs in approximately 5% of pregnant women with onset during pregnancy, and subsiding after parturition. Importantly nearly 50% of women with GDM will eventually develop type 2 diabetes mellitus within 3-5 years post-partum. Moreover, acute and chronic neonatal morbidity and mortality have been described in neonates delivered by women with GDM. Substantial evidence is available documenting that the severity of periodontal disease is increased in patients with type 2 diabetes but no data are available on the effects of GDM on periodontal health. In addition, substantial data is accruing to support earlier observations that the infection and inflammation associated with periodontal disease may have a negative impact on the period of gestation and on fetal growth leading to the birth of preterm, low birth weight infants. Our GENERAL HYPOTHESIS is that women with GDM are at higher risk for developing more severe periodontal disease than women without GDM and that the combination of GDM and periodontal disease will be associated with an increased negative impact on maternal and fetal health. This hypothesis will be tested by collecting (a) clinical oral health data on periodontal status, as well as maternal and fetal outcomes data (Specific Aim 1), (b) microbial dental plaque samples (Specific Aim 2) and (c) serum samples in women with GDM and in non-GDM controls (Specific Aim 3). These prospective clinical data will be correlated with basic science laboratory evaluations of the microflora and host response to provide insight into the pathogenic mechanisms contributing to negative maternal and fetal outcomes associated with inflammatory periodontal disease and GDM. To date, 25 subjects have enrolled in the study. The appropriate data have been collected on all subjects. Enrollment will continue in the coming year. Collected data will be subjected to statistical analyses at the mid-point and at the end of the study.