UKY DENTAL COBRE: BIOINFORMATICS & BIOSTATISTICS CORE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 为子项目列出的总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 生物统计学和生物信息学核心（BBC）将在CBBO/SD项目和试点研究的开发和实施期间提供集中，安全的数据库，研究设计和数据分析的统计咨询以及生物信息学支持。BBC的具体目标是： (1)协助研究者解决与实验设计、样本量确定和数据的统计/生物信息学分析相关的问题， (2)创建一个集中的数据库，以确保收集高质量的数据 (3)根据所有当前监管法规，以最低的项目成本维护所有数据的完整性、机密性和安全性。 (4)定期向中心执行委员会提供临床导向项目的数据库总结，以监测受试者招募和随访。 (5)参与研究生、证书生、博士后研究人员和青年研究人员的培训。 (6)根据CBBO/SD的需要，开发统计和/或生物信息学方面的新方法。 (7)与CBBO/SD研究人员合作，准备发表论文 (8)与研究人员合作，制定有竞争力的研究方案

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Biostatistics and Bioinformatics Core (BBC) will provide a centralized, secure database, statistical consultation on study design and data analysis, and bioinformatics support during development and implementation of the projects and pilot studies in the CBBO/SD. The specific aims of this BBC are: (1) Assist investigators in resolving issues related to experimental design, sample size determinations, and the statistical / bioinformatics analysis of data, (2) Create a centralized database to assure high quality data is collected (3) Maintain the integrity, confidentiality, and security of all data in compliance with all current regulatory statutes but at a minimum cost to the projects. (4) Provide periodic summaries of the database in clinically oriented projects to the Center Executive Committee to monitor subject recruitment and follow-up. (5) Participate in the training of graduate students, Certificate Students, postdoctoral researchers, and young investigators. (6) Develop new methodology in statistics and/or bioinformatics as needed in the CBBO/SD. (7) Collaborate with CBBO/SD investigators in preparing papers for publication (8) Work with investigators in developing competitive research proposals