UKY DENTAL COBRE: BIOINFORMATICS & BIOSTATISTICS CORE

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 生物统计学和生物信息学核心 (BBC) 将提供集中、安全的数据库、研究设计和数据分析的统计咨询，以及 CBBO/SD 项目和试点研究的开发和实施过程中的生物信息学支持。本 BBC 的具体目标是： (1) 协助研究者解决与实验设计、样本量确定以及数据统计/生物信息学分析相关的问题， (2) 创建集中数据库以确保收集高质量的数据 (3) 维护所有数据的完整性、保密性和安全性，遵守所有现行监管法规，但项目成本最低。 (4) 定期向中心执行委员会提供临床导向项目的数据库摘要，以监督受试者招募和随访。 （5）参与研究生、证书生、博士后、青年研究员的培养。 (6) 根据 CBBO/SD 的需要，开发统计和/或生物信息学的新方法。 (7) 与 CBBO/SD 研究人员合作准备发表论文 (8) 与研究者合作制定竞争性研究计划

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Biostatistics and Bioinformatics Core (BBC) will provide a centralized, secure database, statistical consultation on study design and data analysis, and bioinformatics support during development and implementation of the projects and pilot studies in the CBBO/SD. The specific aims of this BBC are: (1) Assist investigators in resolving issues related to experimental design, sample size determinations, and the statistical / bioinformatics analysis of data, (2) Create a centralized database to assure high quality data is collected (3) Maintain the integrity, confidentiality, and security of all data in compliance with all current regulatory statutes but at a minimum cost to the projects. (4) Provide periodic summaries of the database in clinically oriented projects to the Center Executive Committee to monitor subject recruitment and follow-up. (5) Participate in the training of graduate students, Certificate Students, postdoctoral researchers, and young investigators. (6) Develop new methodology in statistics and/or bioinformatics as needed in the CBBO/SD. (7) Collaborate with CBBO/SD investigators in preparing papers for publication (8) Work with investigators in developing competitive research proposals