Commercialisation potential of a decellularised porcine bladder matrix.

我们开发了一种新的方法，通过利用膀胱独特的扩张能力来脱去全层猪膀胱组织的细胞；一项专利正在申请中。合成的生物材料在其非交联型中高度稳定，在细胞培养中无细胞毒性，并保留了天然膀胱的强度和顺应性。在商业化之前，需要对脱细胞的猪膀胱组织进行进一步的临床前评估，以确定基准生物力学特性，调查免疫学状态，并确定生物材料是否能够支持体外和体内的再细胞化。这一信息是必要的，以确定特定的临床用途和针对适当的商业化部门。

We have developed a novel procedure to decellularise full-thickness porcine bladder tissue by utilising the bladder's unique capacity for expansion; a patent is in application. The resultant biometerial is highly stable in its non-cross-linked form, non-cytotoxic in cell culture and retains the strength and compliant properties of the native urinary bladder. Prior to commercialisation, further pre-clinical evaluation of the decellularised porcine bladder tissue is required in order to identify benchmark biomechanical properties, investigate the immunological status and determine whether the biomaterial is able to support both in vitro and in vivo recellularisation. This information is necessary in order to identify specific clinical uses and target appropriate commercialisation sectors.