Nocturia and Chronic Medical illness

描述（由申请人提供）： 此应用程序概述了计划，以进一步我的个人教育和指导初级临床研究人员通过支持从中期职业生涯奖在以病人为导向的研究。一个新的方向，在临床研究中也被描述，特别强调糖尿病的相互作用与排尿和其他下尿路症状（LUTS）。虽然它本身并不危及生命，但它会严重影响患者的生活质量，并可能是整体健康状况不佳的指标。一些证据表明，慢性医学疾病和用于治疗这些疾病的药物可能会影响这些腹泻和其他LUTS的患病率和严重程度。试图缓解腹泻/下尿路症状的医疗保健提供者面临着与医学疾病背景下腹泻/下尿路症状的调查和治疗相关的重大知识缺口，因为每种疾病和合并疾病对这些下尿路症状的影响程度尚不清楚。该提案旨在正式研究糖尿病患者和非糖尿病患者的血糖控制、肾功能和LUTS之间的关系。然后将整合原始研究结果和信息丰富的流行病学数据，开始形成几种慢性医学疾病与腹泻/LUTS相互作用的模型，并开发用于评估和治疗该环境中腹泻患者的算法。所描述的项目也将产生假设，并将作为指导当前和未来的研究员和居民谁选择成为感兴趣的研究这条线的车辆。 K24奖提供的受保护的时间也将允许我继续接受生物统计学教育，并参与生物统计咨询团队的指导活动。根据我提出的研究项目进行肾脏医学的进一步教育也是可行的，可以参加Mines VA医疗中心的教学会议。 最后，工资支持将使我能够继续和扩大我的指导工作，为当前和未来的同事，研究员和居民的利益。

DESCRIPTION (provided by applicant): This application outlines plans to further my personal education and mentoring of junior clinical researchers through support from a Mid-Career Award in Patient Oriented Research. A new direction in clinical research is also described, with specific emphasis on the interaction of diabetes with nocturia and other lower urinary tract symptoms (LUTS). Although not in itself life-threatening, nocturia can severely adversely affect patient quality of life and can be an indicator of poor overall health. Several lines of evidence suggest that chronic medical illnesses and medications used to treat those illnesses may affect the prevalence and severity of those nocturia and other LUTS. Healthcare providers attempting to relieve nocturia/LUTS are faced with a major knowledge gap related to the investigation and treatment of nocturia/LUTS in the setting of medical illness, as the magnitude of the effect of each illness and combined illnesses on those LUTS is unknown. This proposal seeks to formally study the relationship between glycemic control, renal function and LUTS in patients with and without diabetes. The results of this original research and informative epidemiological data will then be integrated to begin to form a model of the interaction of several chronic medical illnesses with nocturia/LUTS, and development of algorithms for the evaluation and treatment of patients with nocturia in that setting. The projects described will also be hypothesis-generating and will serve as vehicles for mentoring of current and future Fellows and Residents who choose to become interested in this line of research. The protected time afforded by the K24 award will also allow my continuing education in biostatistics, and my participation in the mentoring activities of the biostatistical consulting team. Further education in renal medicine in line with my proposed research project will also be feasible, with attendance at didactic sessions within the Mines VA medical center. Finally, salary support will allow me to continue and expand my mentoring efforts for the benefit of current and future colleagues, fellows and residents.