New MRI techniques for cerebrovascular diseases

简介(申请人提供)：格雷戈里·W·阿尔伯斯博士的职业生涯重点是斯坦福大学医学中心以患者为中心的脑血管疾病研究。他的研究成就包括在中风诊断、治疗和预防领域的重大贡献。他还在为脑血管疾病患者制定国家临床实践指南方面发挥了重要作用。他是多名年轻中风研究人员的成功导师，他的八名学员目前在大学医学中心担任全职学术职务。阿尔伯斯博士目前的研究兴趣是评估新的MRI技术的实用性，特别是扩散和灌注MRI，作为急性中风患者的诊断和治疗决策工具。K24奖将使他能够集中精力促进几名初级临床研究人员的职业发展。这项研究提案包括三项由NIH R01资助的拨款。FUSE研究是美国国立卫生研究院资助的一项试点临床试验拨款，旨在确定特定的患者亚组，根据扩散和灌注磁共振成像特征确定，当在中风症状出现后3至6小时内接受静脉溶栓治疗时，这些患者可能对静脉溶栓治疗有良好的反应。这项试点试验将提供设计随机临床试验所需的基本数据，以确定根据特定MRI标准选择的中风患者是否可以在中风发病后3小时以上从静脉溶栓治疗中受益。这项诊断试验是由美国国立卫生研究院资助的一项为期4年的单中心试验，旨在确定扩散和灌注磁共振成像在脑缺血症状出现72小时内出现的患者中的临床实用性。NIH资助的第三笔R01赠款将使用复杂的MRI技术来测量急性中风患者的脑血流灌注，并确定区分临界低灌注度和良性少血症的量化阈值。一项创新的指导计划被提出，该计划将为年轻研究人员在临床研究中的职业生涯做好准备。这项K24研究计划将扩展阿尔伯斯博士作为临床研究员的技能，并使他成为一名更有效的导师。

DESCRIPTION (provided by applicant): Dr. Gregory W. Albers' career focus has been patient-oriented research in cerebrovascular disease at Stanford University Medical Center. His research accomplishments include significant contributions to the fields of stroke diagnosis, treatment and prevention. He has also played a major role in developing national clinical practice guidelines for patients with cerebrovascular disease. He has been a successful mentor for multiple young stroke investigators and eight of his mentees currently hold full-time academic appointments at university medical centers. Dr. Albers' current research interest is evaluating the utility of new MRI techniques, particularly diffusion and perfusion MRI, as diagnostic and therapeutic decision making tools for patients with acute stroke. The K24 Award will allow him to focus his efforts on facilitating the career development of several junior clinical investigators. The research proposal consists of three funded NIH R01 grants. The DEFUSE study is an NIH funded pilot clinical trial grant that aims to identify specific patient subgroups, defined by diffusion and perfusion MRI profiles, who are likely to have a favorable response to intravenous thrombolytic therapy when treated between 3 and 6 hours after stroke symptom onset. This pilot trial will provide essential data needed to design a randomized clinical trial to determine whether stroke patients, selected with specific MRI criteria, can benefit from intravenous thrombolytic therapy beyond 3 hours after stroke onset. The DIAGNOSIS trial is a 4-year, single-center NIH funded trial designed to determine the clinical utility of diffusion and perfusion MRI in patients presenting within 72 hours of the onset of symptoms suggestive of brain ischemia. A third NIH funded R01 grant will employ sophisticated MRI techniques to measure cerebral perfusion in acute stroke patients and determine quantitative thresholds for differentiating critical levels of hypoperfusion from benign oligemia. An innovative mentoring program is proposed that will prepare young investigators for careers in clinical research. This K24 research program will expand Dr. Albers' skills as a clinical investigator and allow him to become a more effective mentor.