Theoretical Population Genetics

描述(由申请者提供)：本修订项目涉及开发新的人口遗传数据统计方法。重点将集中在三个主要领域：群体结构的特征，遗传标记内部和之间以及沿着单倍型的关联模式的特征，以及两个以上等位基因集合的身份状态的特征。理论的发展至少部分是为了应对目前对人类和其他物种进行的大规模SNP调查的需要。 具体主题包括确定特定于人口的人口结构措施的抽样性质，以及比较基于标记和基于特征的人口结构估计数。将对目前定义单倍型区块的方法进行比较，并考虑基于多样性或基于一个标记的列联表和回归分析的替代方法与后续标记的单倍型。将开发出关于一个基因座上两个以上等位基因之间的关联或来自多个基因座的单个等位基因之间的关联的推断方法。

DESCRIPTION (provided by applicant): This revised project is concerned with developing new statistical methodology for population genetic data. Attention will be focused on three main areas: the characterization of population structure, the characterization of the association patterns within and between genetic markers and along haplotypes, and the characterization of the identity status of sets of more than two alleles. Theory will be developed at least in part in response to the needs of current large-scale SNP surveys of humans and other species. Specific topics include determining the sampling properties of population-specific measures of population structure and the comparison of marker- and trait-based estimates of population structure. A comparison will be conducted of current methods for defining haplotype blocks, and consideration of alternative methods based on diversity or on contingency-table and regression analyses of one marker versus haplotypes of subsequent markers. The means for drawing inferences about associations among more than two alleles at one locus, or among single alleles taken from multiple loci will be developed.