Mega 2: Manipulation Environment for Genetic Analyses

Mega2，即遗传分析的操作环境，是一个独特的计算机程序，用于促进 从作为遗传研究一部分收集的数据创建可供分析的数据集。Mega2透明 使用户能够准确、高效地处理基于家庭或病例/对照研究的基因数据。在……里面 除了数据验证检查之外，Mega2还提供了分析设置功能，可供多种选择 常用的基因分析程序。它在遗传学研究中发挥了重要作用。 世界各地的社区。根据这一提议，我们计划使Mega2成为一个强大的开源应用程序， 高度增强的功能，同时应用软件工程中的最佳实践来满足这些关键 开放源码项目的需求：跨操作系统平台的可移植性，能够随着遗传学的需求而发展 研究、广泛的文档、最大限度地实现代码重用以及系统测试、调试和 维修。具体地说，我们计划大幅提升Mega2的S可用性、数据输入处理能力、 其建立目标分析的能力，以及其数据统计的图形表示和存储， 诊断和结果。我们还将开发一个应用程序编程接口并进行改进 文档和教程。Mega2已被用于加速对一大批 复杂的人类疾病。改善这一关键资源将对加快 基因发现过程，这反过来将减轻由于复杂的遗传病造成的医疗负担 我们和世界各地。 相关性：Mega2被用于对复杂人类疾病的遗传学的许多不同研究，使 研究人员快速更改文件格式并准备用于统计分析和透明的文件 准确、高效地处理基因数据。因此，Mega2已经并将继续显著 加快人类复杂疾病易感基因定位和识别。

Mega2, the Manipulation Environment for Genetic Analysis, is a unique computer program for facilitating the creation of analysis-ready datasets from data gathered as part of a genetic study. Mega2 transparently allows users to process genetic data for family-based or case/control studies accurately and efficiently. In addition to data validation checks, Mega2 provides analysis setup capabilities for a broad choice of commonly-used genetic analysis programs. It has served an important role in the genetics research community worldwide. Under this proposal, we plan to make Mega2 a powerful open-source application with highly enhanced capabilities, while applying best practices in software engineering to meet these critical needs of an open-source project: portability across OS platforms, ability to evolve with the needs of genetics research, extensive documentation, maximizing code reuse, as well as systematic testing, debugging and maintenance. Specifically, we plan to significantly improve Mega2's usability, data input handling capabilities, its abilities to set up target analyses, and its graphical presentation and storage of data statistics, diagnostics, and results. We will also develop an Application Programming Interface and improved documentation and tutorials. Mega2 has been used to accelerate gene discovery studies for a large list of complex human diseases. Improving this crucial resource will have a significant impact on speeding up the gene-discovery process, which in turn will ease the healthcare burden due to complex genetic disease in the US and world-wide. Relevance: Mega2 is used in many different studies of the genetics of complex human diseases, enabling researchers to swiftly change file formats and prepare files for statistical analysis and transparently processing genetic data accurately and efficiently. As such, Mega2 has and will continue to markedly accelerate the mapping and identification of susceptibility loci for complex human diseases.