COLLABORATORY EXTENSION TO CHIMERA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。计算机网络技术的进步改革了许多与科学研究相关的做法。高速网络可访问性的提高和高性能计算资源成本的降低创造了一个环境，研究人员可以在其中通过各种基于网络的手段快速传播信息。为了利用这一趋势，我们编写了对嵌合体分子建模系统的扩展，允许地理位置遥远的研究人员实时进行“共享”的分子建模会议。这款名为“协作实验室”的软件创建了一种环境，在这种环境中，连接到“会话”的每个用户都可以平等地控制正在查看的模型(S)，并且任何参与者对模型状态所做的更改(例如，颜色、表示、方向的更改)都会立即传播给其他参与者。因此，在整个会话期间始终保持模型的同步视图。协作实验室旨在通过标准网络连接(使用Internet协议)工作，并已在多个参与者(点对点以及三人或更多人的小组)中进行了测试。该软件与市面上可用的视频会议产品相结合，有效地使分布在全国各地的一群从事同一项目的科学家能够以类似于他们都在同一校园的方式进行他们的研究。过去一年的协作开发主要集中在提高软件的稳定性上。此外，还添加了一些功能，使用户能够考虑特殊的网络条件，包括防火墙或路由器的存在(在DSL网络连接上工作时可能会出现这种情况)。协作实验室定期更新，以支持在协作会议期间使用新的Chimera功能。合作实验室目前正在作为嵌合体分子建模包的一部分进行分发。有关该项目的信息，请访问http://www.cgl.ucsf.edu/Research/collaboratory/。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Advances in computer networking technology have reformed many of the practices associated with scientific research. Increases in accessibility to high speed networks, and the decreasing cost of high-performance computing resources have created an environment in which researchers can rapidly disseminate information through various network-based means. In an effort to take advantage of this trend, we have written an extension to the Chimera Molecular Modeling System, that allows researchers at geographically distant locations to conduct a 'shared' molecular modeling session in real time. This software, called a 'Collaboratory' (collaborative laboratory) creates an environment in which every user connected to a 'session' has equal control over the model(s) being viewed, and a change made by any participant to the state of the models (e.g. change in color, representation, orientation) is instantly propogated to the other participants. Thus, a synchronized view of the models is maintained at all times throughout a session. The Collaboratory was designed to work over a standard network connection (using Internet Protocol), and has been tested with multiple participants (point-to-point, and groups of three or more). In conjunction with commercially available videoconferencing products, this software effectively enables a group of scientists, located throughout the country, all working on the same project, to conduct their research in a manner similar to if they were all on the same campus. Collaboratory development in the past year has focused primarily on increasing the stability of the software. Additionally, features have been added to enable the user to account for special network conditions, including the presence of a firewall or router (as can be the case when working across a DSL network connection). The Collaboratory is regularly updated to support the use of new Chimera features during collaborative sessions. The Collaboratory is currently being distributed as part of the Chimera Molecular Modeling package. Information about this project can be found at http://www.cgl.ucsf.edu/Research/collaboratory/