CHIMERA SOFTWARE DEVELOPMENT

Chimera是我们的下一代分子图形应用程序 其主要设计目标是可扩展性和易用性。 嵌合体是 用Python编写，带有C++扩展，并使用普遍接受的 例如Tk和OpenGL。 此外，奇美拉还利用 本地开发的对象技术框架。 嵌合体 显著改进，以提高便携性和性能。 在大修期间，我们还实施了大约75%的 MidasPlus提供的功能，我们以前的建模系统。 一 还对Chimera进行了一些扩展。 多 序列文件查看器（MSFViewer）和结构比对查看器 （AlignPlot）报告进行了增强，以通过Chimera进行交互 选择机制 两个新的扩展，ViewDock和HearDock， 实现以显示和声音化对接结果，其中包括一组 候选人的模型取向和他们的分数。 最后，在 作为使用MidasPlus实施的概念验证的后续行动，我们 在设计阶段使用奇美拉实现合作实验室。 奇美拉的发展也启发了其他 开发工具。 例如，我们实现了一个程序， 作为C++库接口的输入，并生成必要的代码， 使功能在Python中可用，这既是一个 奇美拉的开发和指挥语言

Chimera is our next generation molecular graphics application whose main design goals are extensibility and ease of use. Chimera is being written in Python with C++ extensions and uses commonly accepted specifications such as Tk and OpenGL. In addition, Chimera also uses the locally developed Object Technology Framework. Chimera was significantly overhauled to improve portability and performance. During the overhaul period, we also implemented roughly 75% of the functionality offered by MidasPlus, our previous modeling system. A number of extensions to Chimera were also implemented. The Multiple Sequence File Viewer (MSFViewer) and structure alignment viewer (AlignPlot) report were augmented to interact through the Chimera selection mechanism. Two new extensions, ViewDock and HearDock, were implemented to display and sonify docking results, which include a set of candidate model orientations and their scores. Finally, in a follow-up to the proof-of-concept implemented using MidasPlus, we are in the design stages of implementing a collaboratory using Chimera. The development of Chimera also inspired the implementation of other development tools. For example, we implemented a program which takes as input a C++ library interface and generates the necessary code to make the functionality available in Python, which is the both a development and command language for Chimera.