ISLET COMPLEX LIPID IN GROUP VIA CALCIUM INDEPENDENT PHOSPHOLIPASE A2 IN B CELL

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。VIA磷脂酶A2组指定iPLA2B不需要钙来激活，受ATP刺激，并且对溴烯醇内酯自杀底物（BEL）的抑制敏感。已经为iPLA2B提出了几个潜在的功能。对iPLA2B蛋白水平的详细表征表明，b细胞表达该酶的多种亚型，我们的研究涉及到不同亚型具有不同的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The group VIA phospholipase A2 designated iPLA2B does not require calcium for activation, is stimulated by ATP, and is sensitive to inhibition by a bromoenol lactone suicide substrate (BEL). Several potential functions have been proposed for iPLA2B. Detailed characterization of the iPLA2B protein level reveals that b-cells express multiple isoforms of the enzyme, and our studies involve the hypothesis that different isoforms have different.