EXERCISE TRAINING ON FRAILTY IN COMMUNITY DWELLING OLDER ADULTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。背景：渐进性阻力训练(PRT)被证明可以增加老年人的肌肉力量和脱脂质量(FFM)。关于PRT对虚弱老年人的瘦体重和脂肪量的影响，现有的信息有限。方法：93名社区久坐的男性和女性，年龄在78岁以上，身体虚弱，用标准化的客观标准定义，参加为期9个月的运动训练试验。参与者被随机分配到对照组(CTL)，进行低强度的家庭锻炼计划，或包括3个月监督的PRT的锻炼训练计划(ET)。结果：在PRT完成3个月后，在等速测力法测量的伸膝最大自愿力产生(平均D+5.3±13 ft/lb比+1.1±11 ft/lb，p=0.05)方面，ET组比CTL组有更大的改善。ET组全身FFM(用双能X线吸收法测得)增加，而CTL组无明显变化(平均D+0.84±1.4 kg比+0.01±1.5 kg，P<0.005)。总脂肪、躯干脂肪、腹部脂肪和皮下脂肪(使用DEXA和1H磁共振成像测量)对PRT的反应没有改变。结论：三个月的PRT使居住在社区的虚弱老年女性和男性的最大自主大腿肌力和全身FFM得到改善。有监督的锻炼计划可能不足以减少这一人群的全身或腹内脂肪面积。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Progressive resistance training (PRT) has been shown to increase muscle strength and fat free mass (FFM) in the elderly. Limited information is available regarding the effects of PRT on lean and fat mass in frail elders. Methods: Ninety-three community-dwelling sedentary men and women, 78 years and older with physical frailty, defined using standardized objective criteria were enrolled in a 9-month trial of exercise training. Participants were randomly assigned to a control group (CTL) that performed low intensity home exercise program, or an exercise-training program (ET) that included 3 months of supervised PRT. Results: After completion of 3 months of PRT, ET subjects had greater improvements than CTL in maximal voluntary force production for knee extension (mean D +5.3 ¿13 ft/lb vs. +1.1¿11 ft/lb, p=0.05) measured using isokinetic dynamometry. Total body FFM (measured using dual energy x-ray absorptiometry, DEXA) increased in the ET group, but not the CTL group (mean D+0.84 ¿1.4 kg vs. +0.01¿1.5 kg, p0.005). Total, trunk, intra-abdominal, and subcutaneous fat mass (measured using DEXA and 1H-magnetic resonance imaging) did not change in response to PRT. Conclusions: Three months of PRT induced improvements in maximal voluntary thigh muscle strength and whole body FFM in frail, community-dwelling elderly women and men. The supervised exercise program may not be sufficient to reduce whole body or intra-abdominal fat area in this population.