High intensity interval training and nicotinamide riboside treatment to enhance functional capacity and reduce frailty during aging

高强度间歇训练和烟酰胺核苷治疗可增强功能能力并减少衰老过程中的虚弱

基本信息

  • 批准号:
    10266089
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-07-01 至 2023-06-30
  • 项目状态:
    已结题

项目摘要

High intensity interval training and nicotinamide riboside treatment to enhance functional capacity and reduce frailty during aging Frailty is a condition of poor physiological reserve that increases susceptibility to falls, hospitalization, disability, and mortality. The incidence of frailty increases after the age 65, growing from 10% to as many as 50% of those 85 years or older; therefore over 9 million veterans are either frail or at risk for frailty. Exercise has proven benefits for frailty, yet older adults rarely attain the recommended 150 minutes a week of moderate intensity continuous exercise (MICT), as lack of time and fear of injury are the most common barriers. High intensity interval training (HIIT) is emerging as an alternative as it can safely provide strength and endurance benefits with lower time commitments than (MICT). Additionally, exercise can boost nicotinamide adenine dinucleotide (NAD+) levels, an essential co-enzyme for mitochondrial and cellular function that declines with aging. Supplementation with nicotinamide riboside (NR) can also increase NAD+, and both interventions are gaining support as a therapeutic strategy for aging and related conditions such as frailty. Therefore, the goals of this project are: 1) compare the impacts of HIIT versus MICT on physical performance, frailty, and lifespan, and 2) examine whether NR can augment the benefits in response to HIIT or MICT. HIIT ± nicotinamide riboside (NR) reduces frailty during aging. The premise for this study is based upon our recently published study demonstrating that a 10 minute long, 3-days a week HIIT regimen enhances physical performance and reduces frailty in aged mice 28 months of age (equivalent to a 65-80 year old human). The hypothesis of this proposal is that HIIT exercise will reduce frailty and increase lifespan, in a manner that is superior to MICT, and that these benefits will be enhanced with NR supplementation. To test this hypothesis, 24-month-old mice will be given HIIT or MICT regimens until end of life to assess survival benefits, while also being longitudinally assessed for improvement in physical performance and frailty. Next, in addition to HIIT or MICT, aged mice will receive placebo or NR supplementation and examined at 28 months of age to assess impacts upon muscle physiology, physical performance, and frailty. This study will provide a clinical trial blueprint for successful implementation of HIIT and NR supplementation in humans, thus permitting the development of personalized interventions that improve the quality of life of the aging veteran population.
高强度间歇训练和烟酰胺核苷治疗增强功能能力

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Bruce R. Troen其他文献

Effects of a 6-Week Treadmill Training With and Without Virtual Reality on Frailty in People With Multiple Sclerosis
为期6周有虚拟现实和无虚拟现实的跑步机训练对多发性硬化症患者虚弱状况的影响
  • DOI:
    10.1016/j.apmr.2024.09.010
  • 发表时间:
    2025-02-01
  • 期刊:
  • 影响因子:
    3.700
  • 作者:
    Tobia Zanotto;Irina Galperin;Danya Pradeep Kumar;Anat Mirelman;Shahar Yehezkyahu;Keren Regev;Arnon Karni;Tanja Schmitz-Hübsch;Friedemann Paul;Sharon G. Lynch;Abiodun E. Akinwuntan;Jianghua He;Bruce R. Troen;Hannes Devos;Jeffrey M. Hausdorff;Jacob J. Sosnoff
  • 通讯作者:
    Jacob J. Sosnoff
Comparative Responsiveness of HL-60, HL-60R, and HL-60R<sup>+</sup> (LRARSN) Cells to Retinoic Acid, Calcitriol, 9 <em>cis</em>-Retinoic Acid, and Sodium Butyrate
  • DOI:
    10.1182/blood.v86.7.2475.2475
  • 发表时间:
    1995-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Kevin B. Atkins;Bruce R. Troen
  • 通讯作者:
    Bruce R. Troen
Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation.
转化小鼠成纤维细胞主要分泌蛋白基因的克隆和表达。
  • DOI:
    10.1016/s0021-9258(19)57386-0
  • 发表时间:
    1988
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Bruce R. Troen;D. Ascherman;Daphne Atlas;Michael M. Gottesman
  • 通讯作者:
    Michael M. Gottesman
Resveratrol: Effects on Lipids and Cardiovascular Risk
白藜芦醇:对血脂和心血管风险的影响
  • DOI:
    10.1007/s12170-012-0289-2
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    1.9
  • 作者:
    E. Cherniack;E. Cherniack;Bruce R. Troen;Bruce R. Troen
  • 通讯作者:
    Bruce R. Troen

Bruce R. Troen的其他文献

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{{ truncateString('Bruce R. Troen', 18)}}的其他基金

Promoting cognitive resilience and reducing frailty in older Veterans with bright light therapy
通过强光疗法提高老年退伍军人的认知能力并减少虚弱
  • 批准号:
    10590503
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
高强度间歇训练(HIIT)可减少老年退伍军人的虚弱并增强其恢复能力
  • 批准号:
    10539160
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
The impacts of vitamin D status and HIIT on physical performance and frailty during aging
维生素 D 状态和 HIIT 对衰老过程中身体机能和虚弱的影响
  • 批准号:
    10229660
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
ShEEP Request for Intracellular and Extracellular Protein Signaling Station (IEPSS)
ShEEP 请求细胞内和细胞外蛋白质信号转导站 (IEPSS)
  • 批准号:
    10178936
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Enhancing Geroscience Scholarship and Faculty Development to Minimize Frailty and Maximize Healthspan
加强老年科学奖学金和教师发展,以最大限度地减少虚弱和最大限度地延长健康寿命
  • 批准号:
    10349503
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Enhancing Geroscience Scholarship and Faculty Development to Minimize Frailty and Maximize Healthspan
加强老年科学奖学金和教师发展,以最大限度地减少虚弱和最大限度地延长健康寿命
  • 批准号:
    9927970
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
High intensity interval training and nicotinamide riboside treatment to enhance functional capacity and reduce frailty during aging
高强度间歇训练和烟酰胺核苷治疗可增强功能能力并减少衰老过程中的虚弱
  • 批准号:
    10663245
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Enhancing Geroscience Scholarship and Faculty Development to Minimize Frailty and Maximize Healthspan
加强老年科学奖学金和教师发展,以最大限度地减少虚弱和最大限度地延长健康寿命
  • 批准号:
    10581712
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
High intensity interval training and nicotinamide riboside treatment to enhance functional capacity and reduce frailty during aging
高强度间歇训练和烟酰胺核苷治疗可增强功能能力并减少衰老过程中的虚弱
  • 批准号:
    9974279
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
ShEEP Request for Keyence BZ-X800E All-in-One Fluorescence Microscope
ShEEP 请求购买 Keyence BZ-X800E 一体式荧光显微镜
  • 批准号:
    9907801
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:

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Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
  • 批准号:
    495182
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    2023
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Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
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RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
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Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
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    2019
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The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
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Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
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Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
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滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
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    2014
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Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
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