UCI UCSD CANCER GENETICS NETWORK

描述：（申请人的描述）用于制造半导体器件的新兴技术 突变检测和高通量基因测序将使 过时的许多以前和一些目前的研究策略， 癌症的遗传流行病学 UCI-UCSD癌症遗传学 网络（UCI-UCSD CGN）将通过现有优势完成 其合作研究者，社区临床医生，现有资源， 以前在癌症遗传流行病学方面的经验。 的基础 新的NCI方向是临床医生的参与，他们的社区， 服务，以及基础科学家和流行病学家。 也是 战略是传播越来越多的遗传信息， 所有参与者，并向受影响的人提供遗传咨询 癌症突变的发现。 UCI-UCSD CGN将作为合作研究的基础设施 研究人类癌症易感性的遗传基础。 第一章 基础设施将包括基本的网络活动。 这些活动 包括招募和跟踪网络参与者， 收集和存储核心信息，维护本地 信息系统，一个核心实验室，用于处理和存储 生物标本的具体项目，并保持 信息和通信技术，以接口与全国 网络 UCI-UCSD CGN将从总人数中招募潜在的注册者 人口约264，450人。 该人群将 包括由于家族史而处于癌症高风险个体，成员 VA沙漠太平洋医疗保健网络，癌症患者，包括 癌症监测计划中的多原发性癌症患者 橙子，圣地亚哥，和帝国县，从社区诊所转诊， 医生，医院，以及癌症幸存者，他们是倡导者的成员， 和社区团体。 一旦注册，网络成员将完成一个 一页纸的基本家族史和危险因素信息访谈， 将每年进行跟踪。 将进行遗传咨询和教育 提供给网络成员和转诊医生。 2)UCI-UCSD CGN将 扩大研究能力，以支持网络活动，特别是 分子遗传学、临床遗传学、遗传咨询和 教育 高质量的主要研究者网络， 共同研究者将为联合研究工作提供基础设施 在科学家和临床医生之间。 UCI-UCSD CGN将赞助科学 研讨会和会议，这将有助于翻译的分子 遗传学研究转化为临床实践。 大部分的元素 我们小组已经建立了拟议的网络， 他们之间的沟通已经到位。

DESCRIPTION: (Applicant's Description) Newly emerging technology for mutation detection and high-throughput sequencing of genes will make obsolete many of the previous and some of the current research strategies in the genetic epidemiology of cancer. The proposed UCI-UCSD Cancer Genetics Network (UCI-UCSD CGN) will be accomplished through the existing strengths of its co-investigators, community clinicians, existing resources, and previous experience in genetic epidemiology of cancer. Fundamental to the new NCI direction is the participation of clinicians, the community they serve, and basic scientists and epidemiologists. Also integral to the strategy is the dissemination of the growing body of genetic information to all participants and the provision of genetic counseling to those affected by the discovery of cancer mutations. The UCI-UCSD CGN will serve as an infrastructure for collaborative research investigations into the genetic basis of human cancer susceptibility. 1) The infrastructure will include basic network activities. These activities include the recruitment and follow-up of Network Participants, the collection and storage of core information, the maintenance of a local informatics system, a core laboratory for the processing and storage of biological specimens for specific projects, and the maintenance of informatics and communications technology to interface with the Nationwide Network. The UCI-- UCSD CGN will recruit potential enrollees from a total population of approximately 264,450 individuals. This population will include individuals at high-risk for cancer due to family history, members of the VA Desert Pacific Health Care Network, cancer patients including those with multiple primary cancer from the Cancer Surveillance Program of Orange, San Diego, and Imperial Counties, referrals from community clinics, physicians, and hospitals, and cancer survivors who are members of advocacy and community groups. Once enrolled, network members will complete a one-page interview of basic family history and risk factor information and will be followed annually. Genetic counseling and education will be made available to network members and referral physicians. 2) UCI-UCSD CGN will expand research capabilities to support Network activities, specifically in areas of molecular genetics, clinical genetics, genetic counseling, and education. A network of top quality principal investigators and co-investigators will provide an infrastructure for joint research efforts between scientists and clinicians. The UCI-UCSD CGN will sponsor scientific seminars and conferences that will facilitate the translation of molecular genetics research into clinical practice. The majority of the elements of the proposed network have already been established by our group and communications among them are in place.