HORMONES, HORMONE RECEPTORS, AND AGING--AGING AND HUMAN ENDOCRINE REGULATION

在一项对11名年龄超过5岁的健康男性进行的研究中，每晚服用2毫克 GHRH 1-29 S.C.连续6周每晚测定磷酸肌酸/磷酸盐 核磁共振波谱的比率和细胞内pH与 生长激素释放激素治疗减少无氧代谢的需要 锻炼身体。在一项为期6个月的生长激素和性类固醇治疗研究中， 年龄超过65岁的53名健康女性和男性的基线数据表明， 自发性生长激素和皮质醇的分泌有不同的关系 男性与男性之间以及身体脂肪、瘦体重和力量的关系。 女人。因此，(1)生长激素和皮质醇似乎具有性别特异性 心血管危险因素；(2)内源性皮质醇分泌可能 与健康人的力量和活动能力下降有关 老年妇女。

In a study of 11 healthy men ages more than 5 y given 2 mg/night of GHRH 1-29 s.c. nightly for 6 weeks measures of phosphocreatine/phosphate ratios and intracellular pH by MRI spectroscopy were consistent with a GHRH treatment effect to reduce the need for anaerobic metabolism during exercise. In a study of GH and sex steroid administration for 6 months, baseline data from 53 healthy women and men more than 65y suggest that there are differing relationships of spontaneous GH and cortisol secretion with one another and with body fat, lean mass, and strength in men vs. women. Thus, (1) GH and cortisol appear to exert gender-specific effects on cardiovascular risk factors, and (2) endogenous cortisol secretion may be related to the declines in strength and mobility which occur in healthy elderly women.