SPORE in Gastrointestinal Cancer

描述(由申请者提供)：本申请为约翰霍普金斯大学医疗机构胃肠道癌症卓越研究专业计划(SPORT)的续展申请，该计划支持一个高度互动、多学科和跨机构的计划。在三个研究计划、四个核心、一个职业发展和一个研究发展计划中提出了七个研究项目，以扩大我们在结直肠癌和胰腺癌方面的转化性研究。 研究计划1：个体化患者管理的基础(项目1A，早期发现人类结直肠癌和胰腺癌，Kinzler和Giardiello博士；1B，通过分子线索进行药物诊断，Kern和Laheru博士)。计划2：开发和了解新的治疗方法(2A，胰腺钙抗原特异性监测和治疗，Jaffee和Laheru博士；2B，优化和监测转移性结直肠钙的C.novvi疗法，周博士和Diaz博士)。方案3：管理和识别可治愈阶段的胰腺肿瘤(3A，家族性胰腺癌风险标记物Hruban，Klein和Goggins；3B，胰腺癌高易感性人群筛查标记物，Goggins和Hruban博士；3C，早期和变异胰腺肿瘤的基础，Maitra，Kern和Hruban博士)。 这些核心支持研究项目(核心1，行政和通信，Scott Kern博士；2，人类组织研究和物流，Ralph Hruban博士；3，家族癌症登记，Frank Giardiello博士；4，统计/生物信息学，Steven Goodman博士。 职业发展计划(Scott Kern博士)帮助新的研究人员的出现，研究发展计划(Bert Vogelstein博士)为创新方向提供快速资金。

DESCRIPTION (provided by applicant): This application for continuation of the Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancer at the Johns Hopkins Medical Institutions supports a highly interactive, multidisciplinary, and inter-institutional program. Seven research projects within three research programs, four cores, a career development and a research developmental program are proposed to extend our translational research in colorectal and pancreatic cancer. Research Program 1: Fundamentals for individualizing patient management (Project 1A, Early detection of human colorectal and pancreatic cancer, Drs. Kinzler and Giardiello; 1B, Pharmacodiagnostics through molecular clues, Drs. Kern and Laheru). Program 2: Developing and understanding novel therapeutics (2A, Antigen-specific monitoring and therapy in pancreatic Ca, Drs. Jaffee and Laheru; 2B, Optimizing and monitoring C. novvi therapy of metastatic colorectal Ca, Drs. Zhou and Diaz). Program 3: Managing and identifying pancreatic neoplasia in the curable stage (3A, Markers for risk in familial pancreatic cancer Hruban, Klein, and Goggins; 3B, Screening markers for persons with high pancreatic cancer susceptibility, Drs. Goggins and Hruban; 3C, Fundamentals of early and variant pancreatic neoplasia, Drs. Maitra, Kern, and Hruban). The cores support the research programs (Core 1, Administration and Communication, Dr. Scott Kern; 2, Human Tissue Research and Logistics, Dr. Ralph Hruban; 3, Familial Cancer Registries, Dr. Frank Giardiello; 4, Statistics/Bioinformatics, Dr. Steven Goodman. The Career Development Program (Dr. Scott Kern) aids the emergence of new investigators and the Research Developmental Program (Dr. Bert Vogelstein) provides rapid funding of innovative directions.