Pacific Ovarian Cancer Research Consortium

描述（由申请人提供）：太平洋卵巢癌研究联盟（POCRC）是一个以社区为基础的、多学科的、转化的研究项目，涉及来自太平洋沿岸几家研究和医疗机构的临床医生、实验室科学家和公共卫生科学家。基于广泛的方法充分利用了当地现有的科学专业知识，并允许汇集临床资源，从而促进了基于人群的研究，尽管卵巢癌的发病率很低。该计划的主题是1)风险建模和疾病的早期检测，2)使用免疫治疗策略预防疾病进展，以及3)基于预测疾病行为的遗传改变的识别的晚期疾病的预后分类和新治疗方法的发展。我们的假设是，通过早期检测，我们可以显著改善结果，因为1)目前可用的治疗方法对局限于卵巢的疾病更有效，2)我们将开发新的，相对无毒的治疗方法，对早期疾病特别有效。分子生物学、免疫学和免疫疗法的工具在转化研究项目中得到强调。POCRC将开展四个研究项目，由四个核心提供支持：领导核心、临床核心、标本核心和信息学核心。我们更新申请中的四个项目中的每一个都与《孢子》指南中概述的翻译领域中的至少一个相关，并且该计划涵盖了所有五个领域。早期检测是改善卵巢癌患者预后的关键，也是我们SPORE的主要重点，也是我们第一个项目的重点。风险建模是我们第二个项目的重点，它是实施早期发现和预防项目所必需的。改善晚期疾病妇女预后的治疗是我们第三个项目的重点，该项目探索使用过继性t细胞治疗消除肿瘤的潜力。鉴定治疗的分子靶点和疾病的预后分类是我们第四个项目的目标，其中包括潜在相关基因的功能表征。所有这些项目都建立在当前供资期间所进行的工作的基础上。发展研究计划和职业发展计划也包括在我们的更新的一部分。

DESCRIPTION (provided by applicant): The Pacific Ovarian Cancer Research Consortium (POCRC) is a community-based, multidisciplinary, translational research program that involves clinicians, laboratory scientists and public health scientists from several research and medical institutions along the Pacific Coast. The broad based approach takes full advantage of the scientific expertise available locally and allows the pooling of clinical resources, thus facilitating population-based studies despite the low incidence of ovarian cancer. The themes of the program are 1) risk modeling and early detection of disease, 2) prevention of disease progression using immunotherapeutic strategies, and 3) prognostic classification and development of novel treatments for advanced disease based on identification of genetic alterations that predict disease behavior. Our hypothesis is that through early detection we can improve outcomes significantly, because 1) currently available treatments are more effective in disease confined to the ovary, and 2) we will develop novel, relatively non-toxic treatments that will be particularly effective in early-stage disease. The tools of molecular biology, immunology and immunotherapy are emphasized in the translational research program. The POCRC will conduct four research projects that will be supported by four cores: a Leadership Core, a Clinical Core, a Specimen Core, and an Informatics Core. Each of the four projects in our Renewal Application relates to at least one of the translational areas outlined in the SPORE guidelines and together the program encompasses all five. Early detection, a key to improved outcomes for women with ovarian cancer and a major focus of our SPORE, is the focus of our first project. Risk modeling, which is needed for implementation of both early detection and prevention programs, is the focus of our second project. Therapy to improve the outcomes for women with advanced disease is the focus of our third project, which explores the potential for eliminating tumor using adoptive T-cell therapy. Identification of molecular targets for therapy and prognostic classification of disease are the goals of our fourth project, which includes functional characterization of potentially relevant genes. All of these projects build on work performed during the current funding period. A Developmental Research Program and a Career Development Program are also included as part of our Renewal.