Pacific Ovarian Cancer Research Consortium

太平洋卵巢癌研究联盟(POCRC)是一个以社区为基础的、多学科的转化性研究计划，来自太平洋海岸六个研究和医疗机构的临床医生、实验室科学家和公共卫生科学家参与其中。这种以社区为基础的方法允许汇集临床资源，以促进基于人群的研究，尽管卵巢癌的发病率很低。该计划的主题是疾病风险和早期检测的生物标记物，预后和治疗的分子靶标，以及免疫治疗的抗原。我们假设，通过早期检测，我们可以显著改善结果，因为目前可用的治疗方法对仅限于卵巢的疾病更有效；新的、毒性较低的免疫治疗方法预计对早期疾病特别有效。POCRC将进行5个转译研究项目，包括使用在临床前样本中验证的血清标记物对高危女性进行的筛查试验，使用靶向微泡改善超声性能的新型成像试验，验证microRNA血浆签名的可接受性，探索恢复野生型BRCA1在对顺铂的耐药性中的功能，以及抗lGFBP2疫苗的第一阶段试验。每个项目涉及孢子指南中概述的至少一个翻译领域，该计划共同解决TRWG确定的6条翻译途径中的5条，所有项目都建立在本供资期间和以前供资期间开展的工作的基础上。发展研究计划和职业发展计划也是我们续订计划的一部分。项目得到领导和行政核心、临床标本管理和表征核心、参与者招募、登记和表征核心以及生物统计和数据管理核心的支持。

The Pacific Ovarian Cancer Research Consortium (POCRC) is a community-based, multidisciplinary, translational research program that involves clinicians, laboratory scientists and public health scientists from six research and medical institutions on the Pacific Coast. The community-based approach allows the pooling of clinical resources to facilitate population-based studies despite the low incidence of ovarian cancer. The themes of the program are biomarkers for risk and early detection of disease, molecular targets for prognosis and therapy, and antigens for immunotherapy. We hypothesize that through early detection we can improve outcomes significantly because currently available treatments are more effective in disease confined to the ovary; new, less toxic immunotherapeutic approaches are expected to be particularly effective in early-stage disease. The POCRC will conduct 5 translational research projects including a screening trial in high-risk women using serum markers validated in preclinical samples, a novel imaging trial using targeted microbubbles to improve ultrasound performance, validation of a microRNA plasma signature for respectability, exploration of restoration of wild-type BRCA1 function in the development of resistance to cicplatin, and a Phase 1 trial of an anti-lGFBP2 vaccine. Each project addresses at least one of the translational areas outlined in the SPORE guidelines and together the program addresses 5 of the 6 translational pathways defined by the TRWG, All projects build on work performed during the current and previous funding periods. A Developmental Research Program and a Career Development Program are also included as part of our Renewal. Projects are supported by a Leadership and Administration Core, a Clinical Specimen Management and Characterization Core, a Participant Recruitment, Enrollment and Characterization Core, and a Biostatistics and Data Management Core.