Training for Integrative Proteomics Technologies(RMI)

来自罗格斯大学和UMDNJ-Robert Wood Johnson医学院(RWJMS)的一个跨机构和跨学科的教员小组建议在蛋白质组学技术领域开发一个跨学科的研究人员培训计划。培训计划将利用校园内全国知名的多学科和跨学科研究计划的基础设施，包括：BioMaPS定量生物学研究所、新泽西州癌症研究所(CINJ)、美国国立卫生研究院蛋白质结构倡议的东北结构基因组联合会(NESG)和Hie蛋白质数据库(PDB)。该培训计划将教育下一代科学家，了解 表征与人类疾病有关的蛋白质的结构和功能。该项目建立在结构生物学、结构和功能基因组学、细胞生物学、计算生物学以及模式生物生物学、发育生物学和癌症研究方面的现有优势和资金充足的计划的基础上。结构生物界通过将X射线结晶学和核磁共振应用于具有重大生物学和医学意义的问题，以及对蛋白质数据库(PDB)的管理，在罗格斯大学/RWJMS建立了国际显赫地位，蛋白质数据库是全球生物学的中心资源。罗格斯大学/RWJMS是东北结构基因组学联盟(NESG)的协调中心，该联盟是NIH蛋白质结构倡议的一个项目，其目标是从人类基因组和模式真核生物的基因组中生产和纯化数百种蛋白质，并确定其中约200-300种蛋白质的实验3D结构。罗格斯大学/RWJMS的研究人员开发和使用真核生物模型系统的社区是国际公认的。其他重要优势包括专注于细菌和真核转录调控的研究。在罗格斯/RWJMS，计算生物学也有很强的传统，研究人员深入研究蛋白质折叠、蛋白质和DNA药物相互作用，以及细胞网络和信号传递的生物信息学和工程学方法。 培训计划将强调团队对与国家健康高度相关的基于蛋白质组的研究项目的方法，包括专注于癌症和传染病的项目。培训计划还将包括蛋白质组学新课程的设计，一系列研讨会，以及每年一次的静修，将所有参与该计划的学生和教职员工聚集在一起。

An inter-institutional and interdisciplinary faculty group from Rutgers University and UMDNJ-Robert Wood Johnson Medical School (RWJMS) proposes to develop an interdisciplinary research workforce training program in Proteomics Technologies. The training program will capitalize on the infrastructure of nationally prominent multidisciplinary and interdisciplinary research programs on campus including: the BioMaPS Institute for Quantitative Biology, the Cancer Institute of New Jersey (CINJ), the Northeast Structural Genomics Consortium (NESG) of the NIH Protein Structure Initiative, and Hie Protein Data Bank (PDB). The training program will educate the next generation of scientists in the concepts and technologies needed for the characterization of the structures and functions of proteins implicated in human disease. This project builds on existing strengths and well-funded programs in structural biology, structural and functional genomics, cell biology, computational biology, as well as model organism biology, developmental biology and cancer research. The structural biology community has established international prominence at Rutgers/RWJMS through applications of X-ray crystallography and NMR to problems of great biological and medical significance and also through its management of the Protein Data Bank (PDB), a worldwide central resource for biology. Rutgers/RWJMS is the coordinating hub of the Northeast Structural Genomics Consortium (NESG), a project of the NIH Protein Structure Initiative, whose goal is to produce and purify hundreds of proteins from the human genome and the genomes of model eukaryotes and to determine experimental 3D structures for some 200 - 300 of these proteins. The community of researchers at Rutgers/RWJMS developing and using eukaryotic organism model systems is internationally recognized. Other significant strengths include research focused on bacterial and eukaryotic transcriptional regulation. At Rutgers/RWJMS there is also a strong tradition in computational biology with researchers delving into protein folding, protein and DNA drug Interactions, and bioinformatic and engineering approaches to cellular networks and signaling. The training program will emphasize team approaches to Proteome-based research projects of high relevance to the nation's health, including projects focused on cancer and infectious diseases. The training program will also include the design of new courses in Proteomics, a seminar series, and an annnual retreat which will bring together all students and faculty participating in the program.