BRAIN VOLUMETRICS IN TRAUMATIC BRAIN INJURY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在加州大学洛杉矶分校脑损伤研究中心登记的创伤性脑损伤患者在入院时、入住ICU期间以及出院后的长期随访中再次接受多次脑MRI扫描。到目前为止的证据显示，这些患者的局部和区域性白质和灰质萎缩随着时间的推移逐渐增加。我们将使用LONI管道V1在全脑和选定的半球区域(包括额叶、基底额叶、海马体、顶叶和枕叶)分析体积测量和皮质提取，并逐一检查血肿和血肿周围区域的体积和体积变化。由此产生的体积和皮质厚度将通过线性混合建模和相关性研究与在同一患者样本中获得的新陈代谢以及神经和心理状态的测量进行分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Traumatic brain injury patients enrolled into the UCLA Brain Injury Research Center receive multiple brain MRI scans at time of admission, during ICU stay, and again during long-term followup after hospital discharge. Evidence to date demonstrates significant localized and regional white-matter and grey-matter atrophy in increments over time in these patients. We will seek to analyze volumetrics and cortical extractions using the LONI Pipeline V1 in the whole brain and in selected regions by hemisphere, including frontal, basal frontal, hippocampal, parietal and occipital regions, and we will also examine volumes and volume changes in hematoma and perihematomal areas on a case-by-case basis. Resulting volumes and cortical thicknesses will be analyzed by linear mixed modeling and by correlation studies with measures of metabolism and neurological and psychological status obtained in the same patient sample.