ARCHIVING DATA FROM IMPLANTABLE CARDIOVERTER DEFIBRILLATORS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。研究人员发现，使用植入式心脏除颤器（ICDs）可以大大降低某些高危心脏病患者的死亡率。目前icd的使用是基础生物医学研究的产物。美国国立卫生研究院资助的TOVA（室性心律失常的触发因素）项目是一项多中心研究，旨在调查危及生命的心律失常的触发原因，并评估现有icd的有效性。它旨在加强基础生物医学和临床研究。预计将有2000名患有icd的患者参与这项研究。从icd中提取的心电图（EGM）和相关数据以专有数据格式存储在软盘上，这些数据格式因设备制造商而异。目前，临床医生和研究人员必须使用不同的编程设备在纸上绘制数据，以便查看和分析它们。在这个项目中，我们正在为TOVA研究开发定制软件，用于创建一个自动化的、基于网络的、可搜索的ICD EGM和相关数据存档系统。这个数据存档系统允许调查人员通过互联网远程上传ICD审讯数据。来自不同制造商的各种ICD型号的数据自动转换为标准的公共格式，并插入数据库系统。研究人员可以通过网络查看和下载所有EGM波形、注释和设备设置参数。研究人员还可以对任何EGM发作进行记录，并可以搜索特定患者或具有特定标准的EGM发作。这个新的数据库系统是对TOVA项目的一个重要贡献，它极大地加快了收集、组织和分析数据的一种令人不满意的方法。该系统还具有加速其他重要研究项目的潜力，这些项目基于与危及生命的室性心律失常相关的EGM特征的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Researchers have found that the death rate in selected high-risk cardiac patients can be sharply reduced with implantable cardioveter defibrillators (ICDs). The current use of ICDs is the outgrowth of basic biomedical research. The NIH-sponsored TOVA (Triggers of Ventricular Arrhythmias) project is a multi-center study for investigating the trigger causes of life-threatening arrhythmias and for evaluating the effectiveness of existing ICDs. It is aimed at strengthening basic biomedical and clinical research. 2000 patients with ICDs are expected to be entered in the study. Electrogram (EGM) and related data interrogated from ICDs have been stored on floppy disks, in proprietary data format that vary widely with the device manufacturer. Currently clinicians and researchers must use different programming devices to plot the data on paper in order to view and analyze them. For this project we are developing customized software for creating an automated, web-based, and searchable ICD EGM and related data archiving system for the TOVA study. This data archiving system allows investigators to remotely upload ICD interrogation data via the Internet. Data from various ICD models of various manufacturers are automatically converted into a standard public format and are inserted into a database system. Researchers can view and download all the EGM waveforms, annotations, and device setting parameters via the web. Investigators can also make notes on any EGM episodes and can search for specific patients or EGM episodes with specified criteria. This new database system is a critical contribution to the TOVA project, greatly accelerating what has been an unsatisfactory method of collecting, organizing and analyzing data. The system also has the potential to accelerate other important research projects that are based on the investigation of the EGM features associated with life-threatening ventricular arrhythmias.