SIGNAL TRANSDUCTION MECHANISMS OF CELL-SURFACE LIGAND-RECEPTOR SYSTEMS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们研究细胞表面受体及其与胞外配体的复合体的结构，以了解跨质膜信号转导的分子机制。正在研究的受体-配体系统包括Eph-受体/eaffins、Neuropilins/信号素和Tie/Angiopoietins。它们参与调节发育中的和成人的神经和心血管系统。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We study the structures of cell-surface receptors and their complexes with extracellular ligands in order to understand the molecular mechanisms of signal transduction across the plasma membrane. The receptor-ligand systems under investigation include Eph-receptors/ephrins, Neuropilins/Semaphorins, and Tie/Angiopoietins. These are involved in regulating the developing and adult nervous and cardiovascular systems.