Training Program in Cardiovascular Biology and Medicine

描述（由申请人提供）： 该培训补助金的主要目的是为心血管生物学和医学的MD，PhD和MD/PhD提供严格的研究培训，最终目标是将学员培养为独立的临床科学家和博士研究人员。培训计划的具体理由是，基础，转化和临床心血管研究需要研究人员在分子和细胞生物学方面具有坚实的基础，并最终形成由具有互补专业知识的MD和PhD研究人员组成的多学科研究合作。宾夕法尼亚心血管研究所提供了一个独特的培训环境，其中包含广泛的基础设施，用于支持多学科研究团队，重点关注CV开发/先天性心脏病，血管生物学/动脉粥样硬化，肌细胞生物学/心力衰竭，通道生物学/电生理学和生物工程/分子成像等战略领域。要求继续为每年6名博士后研究员提供资助，他们将在指定培训员的指导下进行为期2-3年的博士后研究金。从宾夕法尼亚大学临床和基础科学部门挑选了28名由NIH资助的经验丰富的研究人员作为培训人员。Michael S.宾夕法尼亚心血管研究所（CVI）主任Parmacek将继续担任培训项目主任。H博士生理学主席Lee Sweeney和Jonathan A.宾夕法尼亚大学CVI的科学主任爱泼斯坦将担任培训计划的联合主任。学员可以选择参加基础研究或转化/以患者为导向的研究轨道。在每个课程的具体考虑已被赋予培训MD和博士博士后研究员的独特方面。核心课程将是一个良好的监督研究导师持续至少两年。这种培训将由所需的研究生和医学院课程，讲座，研讨会，技能班（医学写作，获得校外支持）和研究道德行为的具体课程补充。培训方案实施了正式的指导制度，并设立了监督委员会，以监测受训人员的进展情况和培训方案的总体目标。该计划的博士前和博士后学员将从宾夕法尼亚大学心脏病学奖学金培训计划，宾夕法尼亚大学联合学位课程（MD/PhD）和生物医学研究生研究（BGS）计划中选出。此外，还实施了一项吸引代表性不足的少数群体成员的战略。该培训计划的跨部门结构为心血管研究提供了无与伦比的培训环境，并直接与NIH路线图保持一致。 (End摘要）

DESCRIPTION (provided by applicant): The primary purpose of this training grant is to provide rigorous research training for MDs, PhDs and MD/PhDs in cardiovascular biology and medicine with the ultimate goal of preparing trainees as independent clinician-scientists and PhD investigators. The specific rationale underlying the training program is that basic, translational and clinical cardiovascular research requires investigators with a strong foundation in molecular and cellular biology and ultimately formation of multi-disciplinary research collaborations composed ofMD and PhD investigators with complementary expertise. The Penn Cardiovascular Institute provides a unique training environment containing extensive infrastructure used to support multi-disciplinary teams of investigators focused in the strategic areas of CV Development/Congenital Heart Disease, Vascular Biology/Atherosclerosis, Myocyte Biology/Heart Failure, Channel Biology/Electrophysiology and Bioengineering/Molecular Imaging. Support is requested for the continued funding of 6 postdoctoral fellows per year who will perform 2-3 year postdoctoral research fellowships mentored by designated trainers. 28 NIH funded, experienced investigators were chosen as trainers from both clinical and basic science departments at the University of Pennsylvania. Dr. Michael S. Parmacek, Director of the Penn Cardiovascular Institute (CVI), will continue to serve as Director of the training program. Drs H. Lee Sweeney, Chairman of Physiology, and Jonathan A. Epstein, Scientific Director of the Penn CVI, will serve as Co-Directors of the training program. Trainees may choose to enroll in either the Basic Research or Translational/Patient-Oriented Research Track. Specific consideration in each curriculum has been given to the unique aspects of training MD and PhD postdoctoral fellows. The core curriculum will be a well-supervised research preceptorship lasting a minimum of two year. This training will be supplemented by required graduate and medical school classes, lectures, seminars, skill classes (medical writing, obtaining extramural support) and specific courses in the ethical conduct of research. The training program has implemented a formal mentoring system and established an Oversight Committee to monitor trainee progress and the overall goals of the training program. Pre- and postdoctoral trainees for this program will be selected from the Penn Cardiology Fellowship Training program, the Penn Combined Degree Program (MD/PhD) and the Biomedical Graduate Studies (BGS) program. In addition, a strategy to attract individuals from under-represented minorities has been implemented. The inter-departmental structure of this training program provides potential for an unparalleled training environment in cardiovascular research and is aligned directly with the NIH Roadmap. (End of Abstract)