Training Grant in Molecular Cardiology

描述（由申请人提供）： 该计划旨在招募和准备医生和博士。科学家成为独立的研究调查员，应用重组DNA技术阐明心血管疾病的基本机制。 培训是密集和全面的，再加上从体外基因转移到转基因和敲除动物的生理和病理应用的各种研究经验，提供一种综合方法，更有可能确保学员在21世纪世纪取得成功。 该方案于1983年启动，获得AHA Bugher基金会培训赠款（1986- 1992年），随后获得INRSA（1992-2003年），共招收了94名学员。 该计划包括三年的医学博士培训。除了心脏病学的临床奖学金培训和两年的博士学位。 每年申请6个职位的资金，其中5个为医学博士培训生和1名博士。实习生。 第三年将由卫理公会医院资助。 该计划的成功表现在我们的毕业生中有85%以上留在学术界，30人被选中参加全国研究竞赛，其中20人获奖。 该Preceptors已经通过培训和研究合作了十多年，与学员有着丰富的经验，所有这些都是由NIH个人，SCOR或计划赠款支持：心脏病学在医学系，和分子和人类遗传学，细胞生物学和儿科部门。 正在进行的研究主题包括：心血管疾病的分子遗传学;凝血和血栓形成的遗传缺陷;脂蛋白疾病的遗传学;通过生长因子、信号转导级联和转录因子调节心脏生长;基因治疗和使用转基因小鼠和同源重组来阐明心脏疾病表型的发病机制。 其他主要特点是：1）每个学员三年的受保护研究时间; 2）生物信息学，遗传学，遗传工程，生物统计学和赠款写作课程; 3）三个SCORs和三个计划项目的核心设施，以促进技术交流;和4）心血管系统分子遗传学综合研讨会。 这种集成设计一直被证明是有效的，在心血管医学分子生物学提供成功的独立和有竞争力的研究者。

DESCRIPTION (provided by applicant): The program is designed to recruit and prepare physician and Ph.D. scientists to become independent research investigators who apply the techniques of recombinant DNA to elucidate fundamental mechanisms of cardiovascular disease. The training is intense and comprehensive, coupled with diverse research experience in physiological and pathological applications ranging from in vitro gene transfer to transgenic and knock-out animals to provide an integrated approach more likely to assure success to the trainee in the 21st century. This program, initiated in 1983, on being awarded the AHA Bugher Foundation Training Grant (1986-92) and subsequently the INRSA (1992-2003), has enrolled a total of 94 trainees. The program consists of three years of training for the M.D. in addition to the clinical fellowship training in cardiology and two years for the PhD. Funding is requested for six positions per year, 5 for M.D. trainees and 1 for the Ph.D. trainee. The third year will be funded by The Methodist Hospital. The success of the program is shown by more than 85% of our graduates remaining in academics and 30 have been selected to participate in national research competitions with 20 winners. The Preceptors have collaborated through training and research for more than a decade, have extensive experience with trainees, all of whom are supported by NIH individual, SCOR, or program project grants located in: Cardiology in the Department of Medicine, and the Departments of Molecular and Human Genetics, Cell Biology, and Pediatrics. Ongoing research themes include: molecular genetics of cardiovascular disorders; genetic defects in coagulation and thrombosis; genetics of lipoprotein disorders; regulation of cardiac growth through growth factors, signal transduction cascades and transcription factors; gene therapy and the use of transgenic mice and homologous recombination to elucidate the pathogenesis of cardiac disease phenotypes. Other major features are: 1) three years protected research time for each trainee; 2) coursework in Bioinformatics, genetics, genetic engineering, biostatistics and grant writing; 3) core facilities of three SCORs and three Program Projects to facilitate technology exchange; and 4) an integrated seminar on molecular genetics of the cardiovascular system. This integrated design has consistently proven to be effective in providing successful independent and competitive investigators in molecular biology of cardiovascular medicine.