NIAMS - Research Training in Dermatology

描述(由申请人提供)： 通过这次竞争更新，耶鲁大学皮肤科建议继续其在培养未来皮肤病学术领袖方面的强劲记录。在过去十年中，这项T32计划资助了16名完成专业和/或研究培训的一年或多年的学员，其中13名(80%)随后获得了学术部门或联邦政府的全职任命，其中12人承担了主要的基础和/或临床研究任务。我们将继续重视发展MD和MD/PhD皮肤科医生的研究技能，尽管被认为可能对皮肤病学研究做出实质性贡献的博士候选人将被考虑填补空缺职位。我们系提供了一个有利于培养研究皮肤科医生的环境：21名全职初级皮肤科教员中有16人积极从事基础和/或临床研究，9人将50%的精力投入到这类研究活动中。在美国国立卫生研究院赞助的耶鲁皮肤病研究核心中心的帮助下，我们以皮肤科为基础的研究人员与耶鲁其他系的其他主要研究员进行了广泛的互动，其中包括14名被指定为此培训计划导师的研究人员，其中6人拥有皮肤科的联合任命。由于我们认为这最有利于学员智力独立的发展，并有助于将新的科学技能引入皮肤病学界，因此，在我们系外接触耶鲁大学杰出的基础科学家将继续是强制性的。与过去两个资助期一样，每名学员将有两名顾问，一名在皮肤科内，一名在皮肤科外。在主要实验室经验在系外的通常情况下，在指定的非皮肤科基础科学家或其他同等个人的指导下，皮肤科教员顾问将监督受训人员的进展，并证明培训计划与受训人员在该专业的未来相关。如果学员直接在皮肤科实验室工作，非皮肤科耶鲁顾问将确保接触到额外的基础技术、科学审查、研讨会和同龄人小组互动。将继续在与皮肤生物学有关的广泛研究领域提供培训机会：例如，正常和恶性T细胞、B细胞和树突状细胞的细胞和分子免疫生物学；自身免疫；疫苗开发；黑素细胞生物学和黑色素瘤；角质形成细胞生物学和致癌；基因治疗；微血管结构/功能和伤口愈合。

DESCRIPTION (provided by applicant): Through this competitive renewal Yale University Department of Dermatology proposes to continue its strong track record of training future leaders of academic dermatology. Of the sixteen trainees supported for one or more years by this T32 program during the past ten years and who have completed their subspecialty and/or research training, thirteen (80%) subsequently received full-time appointments to academic departments or the federal government, with major basic and/or clinical research commitments for twelve of them. Our emphasis on the development of the research skills of MD and MD/PhD dermatologists will be maintained, although PhD candidates judged likely to make substantive contributions to investigative dermatology will be considered for unfilled positions. Our department provides an environment conducive to training research dermatologists: sixteen of the twenty-one fulltime primary Dermatology faculty are actively engaged in basic and/or clinical research and nine spend > 50% effort on such research activities. Facilitated by the NIH-sponsored Yale Skin Diseases Research Core Center, our Dermatology-based research faculty interacts extensively with other leading investigators with primary appointments in other Yale departments, including fourteen researchers designated as preceptors for this training program, six of whom hold joint appointments in Dermatology. Because we consider it most conducive to the trainees' development of intellectual independence and to the introduction of new scientific skills into the dermatology community, substantial exposure to outstanding Yale University basic scientists outside of our department will continue to be mandatory. As during the past two funding periods, each trainee will have two advisors, one inside and one outside the Dermatology Department. In the usual circumstance in which the principal laboratory experience is outside the department, under the mentorship of one of the designated non-dermatologist basic scientists or another equivalent individual, the Dermatology Department faculty advisor will monitor progress of the trainee and certify that the training program is relevant to the trainee's future in the specialty. In the event that the trainee works directly in a dermatology laboratory, the non-dermatology Yale advisor will ensure exposure to additional basic technology, scientific review, seminars and peer group interactions. Training opportunities will continue to be available throughout a broad range of research arenas relevant to cutaneous biology: e.g., cellular and molecular immunobiology of normal and malignant T cells, B cells and dendritic cells; autoimmunity; vaccine development; melanocyte biology and melanoma; keratinocyte biology and carcinogenesis; gene therapy; microvasculature structure/function and wound healing.