GS-MS Analysis of New Catalytic Reactions via C-H Activation

催化C-H活化使原本需要几个离散步骤的化学过程在一步中干净而高效地进行。因此，这种反应比它们寻求取代的过程更具成本效益和环境友好。在本研究过程中，我们打算使用GC-MS来帮助启动和开发新的C-H活化过程，以实现广泛的新的C-C键形成反应。建议的研究大致可分为两个领域：(A)催化分子间邻位芳基化反应及相关反应的发展；(B)通过C-H活化一锅法合成苯并[b]-和二苯并[b，d]-稠合杂环的进展。新的方法学将被应用于选择感兴趣的目标的新合成。

Catalytic C-H activation allows chemistry that would otherwise take several discrete steps to be performed cleanly and efficiently in one step. Therefore such reactions are more cost effective and environmentally more benign than the processes they seek to replace.During the course of this research we intend to use GC-MS to help enable the inception and development of novel C-H activation processes in order to realise a wide range of new C-C bond-forming reactions. The proposed research can be broadly divided into two areas: (a) the development of catalytic intermolecular ortho-specific arylations and related reactions and (b) the development of one-pot syntheses of benzo[b]- and dibenzo[b,d]-fused heterocycles via C-H activation. The new methodologies will be applied to the novel synthesis of selected interesting targets.