THE GUT MICROBIOME IN DEVELOPMENT, HEALTH, AND DISEASE

描述(申请人提供)：人体含有的微生物至少是人体细胞的十倍。最近的数据迫使人们认真考虑共同进化的微生物-宿主伙伴关系。事实上，我们是超级有机体，是许多物种的复合体。这一新兴的研究领域对人类发展、健康、动态平衡和疾病有着巨大的影响，而人类肠道生物量是这些生物体中最大的一部分。出于这些原因，我们将与北美儿科胃肠病、肝病和营养学会合作，提供一门关于人类肠道微生物群在发育、健康和疾病方面的课程。该课程将向儿科、内科、免疫学、微生物学、牙科、皮肤病和其他领域的广泛研究人员开放，并以该学科先驱小组的讲座为特色。将涵盖的主题包括肠道微生物区系在肠道和肠外炎症中的作用、免疫调节和益生菌的生物学。将特别重视受训人员，并为在这一多方面领域的职业生涯做准备。将强调与肠道微生物组研究有关的生物学概念。预计关于这一专题的首期课程将促使广泛的调查人员获得与这一领域有关的技术培训。由于微生物组研究正在如此迅速地改变人类生物学的基本概念，而且该领域的受训者如此之少，研究人员了解这些新兴数据至关重要，以便他们能够帮助将这些信息快速有效地转化为有用的知识，这是本课程的目标。

DESCRIPTION (provided by applicant): People contain at least ten-fold more microbial than human cells. Recent data compel serious consideration of co-evolved microbial-host partnerships. We are, in fact, super-organisms and composites of many species. This nascent field of study has tremendous implications for human development, health, homeostasis, and disease, and the human enteric biomass represents the largest fraction of these organisms. For these reasons, we will present a course on the human intestinal microbiome in development, health and disease, in conjunction with the North American Society for Pediatric Gastroenterology Hepatology and Nutrition. The course will be open to a wide community of investigators in pediatrics, internal medicine, immunology, microbiology, dentistry, dermatology, and other fields, and feature lectures from a panel of pioneers in this discipline. Topics to be covered include the role of the intestinal microbiota in intestinal and extraintestinal inflammation, immune regulation, and the biology of probiotics. There will be particular emphasis on trainees, and preparation for careers in this multifacetted field. Biologic concepts related to the study of the intestinal microbiome will be emphasized. It is anticipated that this inaugural course on this topic will prompt a wide range of investigators to obtain training in techniques relevant to this field. Because microbiome studies are changing basic concepts of human biology so rapidly, and because so few trainees in this field are in the pipeline, it is critical that investigators learn about these emerging data, so that they can help convert this information into useful knowledge rapidly and efficiently, which is the goal of the course.