Lungs, microbes and the developing neonate.
Lungs, microbes and the developing neonate.
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作者：
Warner BB;Hamvas A
Microbes are ubiquitous on the human body and comprise approximately 90% of the cells and 99% of the genes of the human supra-organism. High throughput sequencing technology has permitted the development of culture-independent means to identify the microbiota that are unique to the various microenvironments of the body and probably contribute some function. Although the respiratory tract interfaces with the environment, the lungs were always thought to be a sterile environment until recently when these techniques were applied to healthy and disease states. Further, there appears to be a complex interplay between the development of the gastrointestinal and respiratory microbiota and the regulation of immune function. The contribution of this dynamic metabolic mass to respiratory disease in the newborn is unknown. This article will review emerging data from recent human and murine studies that suggest there is a microbial influence on the development of respiratory disease but it will also highlight many of the gaps that remain in understanding the function of the respiratory microbiome.
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影响因子：
30.3
作者：
Cahenzli J;Köller Y;Wyss M;Geuking MB;McCoy KD
通讯作者：
McCoy KD
影响因子：
6.4
作者：
Madan JC;Koestler DC;Stanton BA;Davidson L;Moulton LA;Housman ML;Moore JH;Guill MF;Morrison HG;Sogin ML;Hampton TH;Karagas MR;Palumbo PE;Foster JA;Hibberd PL;O'Toole GA
通讯作者：
O'Toole GA
影响因子：
3.7
作者：
Erb-Downward JR;Thompson DL;Han MK;Freeman CM;McCloskey L;Schmidt LA;Young VB;Toews GB;Curtis JL;Sundaram B;Martinez FJ;Huffnagle GB
通讯作者：
Huffnagle GB
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
17.1
作者：
Aagaard K;Ma J;Antony KM;Ganu R;Petrosino J;Versalovic J
通讯作者：
Versalovic J