Transplantation Immunology

描述(由申请人提供)： 这是一个“移植免疫学”会议的部分资金申请，该会议将于2008年7月13-18日在康涅狄格州纽黑文举行。这次会议是在2002年、2004年和2006年在科罗拉多州萨克斯顿的佛蒙特河和斯诺马斯成功举办的关于同一主题的FASE B夏季研究会议之后举行的。2008年的会议将聚焦于先天免疫学和获得性免疫学的分子和细胞方面最重要的最新进展，以及与更好地理解移植排斥和耐受的机制基础直接相关的技术进步。同样重要的是，这些发现对改进细胞和器官移植排斥反应的治疗方法的发展具有重要意义，这最终可能导致临床移植耐受的一致实现。会议的重点将放在最新的见解上，会议将分为8个会议，专门讨论1)天然免疫细胞2)树突状细胞；3)免疫细胞迁移和成像；4)T细胞激活和记忆；5)调节细胞；6)胰岛移植和细胞治疗；7)B细胞、异体和异种移植中的抗体以及8)免疫监测。这次会议的一个重要方面将是具有基础免疫学和分子遗传学/生物学专业知识的科学家与移植科学家和临床医生之间的互动。大约80-100名参与者将从最有可能分享最新新知识并有助于促进思想/概念交流的调查人员中挑选出来。组织者不断努力将妇女、少数群体和残疾人纳入规划/方案发展的每一步。演讲者将是那些最近做出最重大贡献的人。将有一次海报展示环节。会议还将为来自广泛次级专业的贡献者之间的对话提供一个重要论坛。汇总的结果应该是对这一快速发展的应用生物医学科学领域的概述和综合观点/共识。一个重要的目标将是评估未来的研究方向，以及对当代移植免疫学的“前沿”研究进行批判性评估。2008年FASE B夏季移植免疫学研究会议将聚焦于先天免疫学和获得性免疫学分子和细胞方面最重要的最新发展，以及与更好地理解移植排斥和耐受的机制基础直接相关的技术进步。这次会议的一个重要方面将是具有基础免疫学和分子遗传学/生物学专业知识的科学家与移植科学家和临床医生以及受训人员之间的密切互动。一个重要的目标将是评估未来的研究方向，以及对当代移植免疫学的“前沿”研究进行批判性评估。

DESCRIPTION (provided by applicant): This is an application for partial funding of a conference on "Transplantation Immunology" that will be held under the auspices of FASEB in New Haven, Connecticut, July 13-18, 2008. This conference follows the successful 2002, 2004 and 2006 FASEB Summer Research Conferences on the same topic held at Saxton's River Vermont and Snowmass, Colorado. The 2008 conference will target the most important recent developments in molecular and cellular aspects of innate and adaptive immunology, and technologic advances that have direct relevance to improved understanding of the mechanistic basis of transplant rejection and tolerance. Equally significant, are the implications of these findings for the development of improved therapies of cell and organ graft rejection, which may lead ultimately, to the consistent achievement of clinical transplantation tolerance. Emphasis will be placed on the most recent insights and the meeting will be divided into 8 sessions that will be devoted to 1) Innate Immune Cells 2) Dendritic Cells; 3) Immune Cell Migration and Imaging; 4) T cell Activation and Memory; 5) Regulatory Cells; 6) Islet Transplantation and Cell Therapy; 7) B cells, Antibodies in Allo- and Xeno-transplantation and 8) Immunological Monitoring. An important aspect of this conference will be the interaction between scientists with expertise in basic immunology and molecular genetics/biology and transplantation scientists and clinicians. Approximately 80-100 participants will be selected from amongst those investigators most likely to share the most recent new knowledge and contribute to stimulating exchange of ideas/concepts. The organizers have continually strived to include women, minorities and disabled individuals at each step of planning/program development. Speakers will be those who have made the most significant recent contributions. There will be one poster presentation session. The conference will also provide an important forum for dialogue between contributors from a broad range of subspecialties. The aggregate result should be an overview and integrated perspective/consensus of this rapidly moving field of applied biomedical science. An important goal will be the evaluation of future research directions, as well as critical appraisal of contemporary "cutting edge" research in Transplantation Immunology. The 2008 FASEB Summer Research Conference on Transplantation Immunology will target the most important recent developments in molecular and cellular aspects of innate and adaptive immunology, and technologic advances that have direct relevance to improved understanding of the mechanistic basis of transplant rejection and tolerance. An important aspect of this conference will be the close interaction between scientists with expertise in basic immunology and molecular genetics/biology and transplantation scientists and clinicians, as well as the trainees. An important goal will be the evaluation of future research directions, as well as critical appraisal of contemporary "cutting edge" research in Transplantation Immunology.