DNA Replication and Genome Integrity

简介（由申请人提供）：第五届两年一次的索尔克-加州理工学院DNA复制和基因组完整性会议将于2008年7月18日至7月22日在加州拉霍亚的索尔克研究所举行，此后每隔两年举行一次。这次会议将为学生、博士后、教授和生物技术研究人员提供多达350个名额，以会面和讨论过去一年的新发现。由于位于西海岸，预计西海岸和太平洋实验室的参与将会增加。这次会议的目的是满足由于这一领域的活动迅速增加而产生的关于这一主题的年度会议的需要。这一领域的进展正在继续对与人类健康相关的问题产生重大影响，包括癌症的病因、诊断和治疗、衰老以及与发育、免疫系统和神经变性相关的无数疾病。会议的基本主题将是考虑基因组的不稳定性，以鼓励对细胞复制和修复系统之间的联系有更深的理解。杰出的研究人员被邀请担任主席，专门讨论起始，叉蛋白，重组，DNA修复，检查点和基因组完整性，端粒，染色质结构和表观遗传学。这些椅子将深入介绍每个领域中最重要的概念和未解决的问题。所有其他演讲和与会者将从摘要中选择，以确保展示研究的前沿，并鼓励年轻研究人员积极参与。索尔克会议中心经验丰富的工作人员将管理会议。科学组织者是索尔克研究所的杰弗里·沃尔和马修·韦茨曼，加州理工学院的朱迪思·坎贝尔，南加州大学的苏珊·福斯堡和奥斯卡·阿帕里西奥。这次会议在智力上、时间上和地理上补充了目前在奇数年在冷泉港举行的两年一次的DNA复制会议。总之，会议旨在显著扩大真核生物DNA复制面临的最热门问题的讨论。特别是，西海岸的场地应该为那些由于成本较高而无法参加东海岸会议的学生和博士后提供额外的选择。与会者对前四次会议的回顾证实了它的巨大成功。

DESCRIPTION (provided by applicant): The fifth biennial Salk-Caltech Conference on DNA Replication and Genome Integrity will be held at the Salk Institute, La Jolla, California, July 18-July 22, 2008 and henceforth in even years. The conference will provide up to 350 places for students, postdocs, professors and biotechnology researchers to meet and discuss novel findings of the past year. Due to its West coast location, increased participation from West coast and Pacific labs is expected. The conference is designed to fulfill the need for an annual conference on this topic generated by the rapidly increasing activity in this field. Advances in this area are continuing to impact significantly on issues related to human health, including the etiology, diagnosis and treatment of cancer, aging, and myriad diseases related to development, the immune system, and neural degeneration. The underlying theme of the meeting will be consideration of genomic instability, to encourage a deeper understanding of links between cellular replication and repair systems. Outstanding researchers have been invited to serve as chairs in sessions devoted to Initiation, Fork proteins, Recombination, DNA Repair, Checkpoints and Genome Integrity, Telomeres, Chromatin Structure and Epigenetics. These chairs will provide in-depth introductions to the most important concepts and unresolved problems in each field. All other presentations and attendees will be chosen from abstracts to ensure that the forefront of research is presented and to encourage active participation of younger researchers. Experienced staff of the state of the art Salk Conference Center will administer the meeting. Scientific organizers are Geoffrey Wahl and Matthew Weitzman, of the Salk Institute, Judith Campbell, California Institute of Technology, Susan Forsburg and Oscar Aparicio of Univ. of Southern California. This conference complements intellectually, temporally, and geographically the current biennial DNA replication meeting held at Cold Spring Harbor in odd-numbered years. In summary, the meeting is designed to significantly broaden discussion of the most topical issues confronting eukaryotic DNA replication. In particular, the West Coast venue should provide an additional option for students and postdocs who have been unable to attend East Coast conferences due to the greater cost. Participants' reviews of the first four meetings confirm its great success.