PRCC/MDACC:Partners for Excellence in Cancer Research

这是波多黎各大学综合癌症中心（UPRCCC）的重新提交， 德克萨斯大学M. D.安德森癌症中心（MDACC）卓越研究伙伴关系 格兰特，其中涉及的意见和建议，从1）总结声明，2）NCI现场访问， 3）IAC和PSC委员会。在这一应用中加强的领域包括：领导， 沟通、委员会监督、评价、职业发展和指导。在这方面提供的资金 奖金将用于：1）支持3个癌症生物学和预防的完整项目和1个试点项目， （2）加强现有合作，建立新的合作;（3）增加 教师/学员参与培训计划，4）扩大我们的推广计划的努力，以影响 5）巩固和稳定UPRCCC的基础设施建设。 研究赠款包括目标1）开发新的癌症成像技术，2）调节RNA， 真核细胞，3）通过酒精和烟草联合治疗降低癌症风险，以及4）评估 胰岛素抵抗综合征作为子宫内膜癌危险因素的作用。外展计划， 被添加到原来的赠款年中3，已扩大到包括与烟草有关的癌症， 以及乳腺癌、宫颈癌和HPV。培训方案的范围也有所扩大， 教师和学员通过全面的职业发展和指导培训计划。 最初的赠款（2002年）是为了建立一个全面的长期互利 目标和消除癌症健康差距的关系。最初的两个短期目标 建议得到满足：1）发展独立的癌症研究调查员，2）建立一个强大的工作 建立在互惠互利、优势互补基础上的关系。第三个长期目标 伙伴关系是为了重新获得UPRCCC的NCI称号。到目前为止，伙伴关系已经奠定了基础， 进行动态协作，致力于增强每个合作伙伴的优势， 合伙人的弱点该伙伴关系还促进了2004年通过的两项主要法律。 波多黎各，其中一个项目导致为建立基础设施拨款， 为UPRCCC招募顶尖的教师截至2008年，伙伴关系远未达到其长期目标， 重新获得UPRCCC的NCI-designation的目标。为U 54重新提交提供资金至关重要， 保持伙伴关系在癌症研究、培训和外联方面的共同努力的势头。 相关性（参见说明）： 这一重新提交的文件旨在促进和支持普审委与医务和药物滥用问题咨询委员会之间的现有合作。 通过解决癌症在发病率、患病率、死亡率和负担方面的差异， 西班牙裔人口在美国，该伙伴关系将努力减少这些差异，通过努力， 研究、推广和培训。伙伴关系的贡献还将有助于建立一个更强大的国家 通过发展一批训练有素的西班牙裔癌症研究人员，实施癌症计划。

This is a resubmission for The University of Puerto Rico Comprehensive Cancer Center (UPRCCC) and The University of Texas M. D. Anderson Cancer Center (MDACC) Partnership for Excellence in Research Grant, which addresses comments and recommendations from the 1) summary statement, 2) NCI Site Visit, and 3) IAC and PSC Committees. Areas strengthened in this application include: leadership, communication, committee oversight, evaluation, career development and mentorship. Funds granted in this award will be used to: 1) support 3 full projects in cancer biology and prevention and 1 pilot project in epidemiology, 2) enhance existing collaborations and establish new collaborations, 3) increase faculty/trainee participation in the training program, 4) expand efforts in our Outreach Program to impact a larger audience, and 5) fortify and stabilize the infrastructure developing at the UPRCCC. Research grants included target 1) developing new cancer imaging techniques, 2) regulating RNA in eukaryotic cells, 3) reducing cancer risk through combined alcohol and tobacco treatment and 4) assessing the role of insulin resistance syndrome as a risk factor for endometrial cancer. The Outreach Program, which was added into the original grant mid-year 3, has been expanded to include cancer related to tobacco, as well as breast, cervical and HPV. The Training Program has also been expanded in scope to impact more faculty and trainees through a comprehensive career development and mentorship training program. The original grant (2002) was awarded to establish a comprehensive long-term mutually beneficial relationship to target and eradicate cancer health disparities. The two short term objectives of the original proposal were met: 1) develop independent cancer research investigators and 2) establish a strong working relationship based on mutual benefit, identified strengths and reciprocity. The 3rd long-term objective of the Partnership is to regain NCI-designation for the UPRCCC. Thus far, the Partnership has set the foundation for a dynamic collaboration dedicated to enhancing each partner's strengths and eliminating each partner's weaknesses. The Partnership has also served as the catalyst for two major laws passed in Puerto Rico, one of which resulted in the allocation of funding for establishing the infrastructure and recruiting top notch faculty to the UPRCCC. As of 2008, the Partnership is far from reaching its long-range goal of regaining NCI-designation for the UPRCCC. Funding for the U54 resubmission is critical to maintain the momentum of the Partnership's joint efforts in Cancer Research, Training and Outreach. RELEVANCE (See instructions): This resubmission seeks to foster and support an existing collaboration between the UPRCCC and MDACC. By addressing the differences in incidence, prevalence, mortality, and burden of cancer that exist among Hispanic populations in the US, the Partnership will strive to reduce these differences through efforts in Research, Outreach, and Training. Partnership contributions will also aid in building a stronger national cancer program through the development of a pipeline of well-trained, Hispanic cancer researchers.