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Induction and Inhibition of IgE-Mediated Hypersensitivity to Vaccines

Induction and Inhibition of IgE-Mediated Hypersensitivity to Vaccines
IgE 介导的疫苗超敏反应的诱导和抑制
批准号：
7592344
负责人：
Calman Prussin
金额：
$21.9万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7592344
关键词：
AllergicAnaphylaxisAntigensCD4 Positive T LymphocytesClinicalDetectionExtrinsic asthmaFrequenciesFutureGoalsIgEImmediate hypersensitivityImmune responseIndividualInfectious AgentInfluenzaInterferon Type IIInterleukin-4Interleukin-5LifeMeasuresMediatingMedicinePatientsPrimary Health CarePublic HealthT-Cell ProliferationT-LymphocyteTechniquesVaccine AntigenVaccinescytokineresponsetoolvaccine delivery

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中文摘要
翻译
我们研究了过敏性哮喘的特应性患者与非特应性对照者对疫苗的免疫反应是否在数量上不同的问题。我们测定了过敏性哮喘和非过敏性对照受试者中流感抗原特异性T细胞的频率和细胞因子谱。各组之间在个体细胞因子（IL-4、ifn - γ、IL-5）、IL-4: ifn - γ的比例或CD4 T细胞增殖方面均无显著差异。这些结果表明，使用现有的抗原特异性反应检测技术，T细胞细胞因子对流感的反应在特应性和非特应性个体之间没有显着差异。
英文摘要
We examined the question of whether atopic patients with allergic asthma have a quantitatively different immune response to vaccines than do non-atopic control subjects. We determined the frequency and cytokine profile of influenza antigen specific T cells in allergic asthmatic and non-allergic control subjects. No significant differences between the groups were seen in either the individual cytokines (IL-4, IFN-gamma, IL-5), the ratio of IL-4:IFN-gamma, or in CD4 T cell proliferation. These results indicate that using available techniques for detection of antigen specific responses, T cell cytokine responses to influenza do not differ markedly between atopic and non-atopic individuals.
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